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Construction and iterative redesign of synXVI a 903 kb synthetic Saccharomyces cerevisiae chromosome.
Nat Commun
January 2025
School of Natural Sciences, and ARC Centre of Excellence in Synthetic Biology, Macquarie University, Sydney, Australia.
The Sc2.0 global consortium to design and construct a synthetic genome based on the Saccharomyces cerevisiae genome commenced in 2006, comprising 16 synthetic chromosomes and a new-to-nature tRNA neochromosome. In this paper we describe assembly and debugging of the 902,994-bp synthetic Saccharomyces cerevisiae chromosome synXVI of the Sc2.
View Article and Find Full Text PDFElectrostatically tuning radical addition and atom abstraction reactions with distonic radical ions.
Chem Sci
January 2025
Molecular Horizons and School of Chemistry and Molecular Bioscience, University of Wollongong Wollongong New South Wales 2522 Australia
Although electrostatic catalysis can enhance the kinetics and selectivity of reactions to produce greener synthetic processes, the highly directional nature of electrostatic interactions has limited widespread application. In this study, the influence of oriented electric fields (OEF) on radical addition and atom abstraction reactions are systematically explored with ion-trap mass spectrometry using structurally diverse distonic radical ions that maintain spatially separated charge and radical moieties. When installed on rigid molecular scaffolds, charged functional groups lock the magnitude and orientation of the internal electric field with respect to the radical site, creating an OEF which tunes the reactivity across the set of gas-phase carbon-centred radical reactions.
View Article and Find Full Text PDFIn search of herbistasis: COT-metsulfuron methyl displays rare herbistatic properties.
Chem Sci
January 2025
School of Chemistry and Molecular Biosciences, University of Queensland Brisbane 4072 Queensland Australia
Weed management is an essential intervention for maintaining food security and protecting biodiversity but is heavily reliant on chemical control measures (, herbicides). Concerningly, only one herbicide has been developed with a new mode of action (MOA) since the 1980s. Therefore, alternative strategies for preventing weed growth need to be explored.
View Article and Find Full Text PDFInvestigation and management of resistant hypertension: British and Irish Hypertension Society position statement.
J Hum Hypertens
January 2025
Division of Experimental Medicine, University of Cambridge, Addenbrooke's Hospital, Cambridge, UK.
Article Synopsis
- People with resistant hypertension (RH) face a greater risk of serious heart-related issues, prompting the British and Irish Hypertension Society to recommend specialist guidance for better blood pressure control.
- The position statement offers a practical framework for diagnosing and managing adults with RH, while also addressing the current evidence gaps in the field.
- The overall goal is to enhance the quality and consistency of care for individuals with RH throughout the UK and Ireland.
Implementation and validation of face de-identification (de-facing) in ADNI4.
Alzheimers Dement
November 2024
Northern California Institute for Research and Education, San Francisco Veterans Affairs Medical Center, San Francisco, California, USA.
Introduction: Recent technological advances have increased the risk that de-identified brain images could be re-identified from face imagery. The Alzheimer's Disease Neuroimaging Initiative (ADNI) is a leading source of publicly available de-identified brain imaging, who quickly acted to protect participants' privacy.
Methods: An independent expert committee evaluated 11 face-deidentification ("de-facing") methods and selected four for formal testing.
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