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Microvascular Metrics on Diabetic Retinopathy Severity: Analysis of Diabetic Eye Images from Real-World Data.
Biomedicines
December 2024
BCN Peptides, S.A., Polígono Industrial Els Vinyets-Els Fogars II, Sant Quintí de Mediona, 08777 Barcelona, Spain.
To quantify microvascular lesions in a large real-world data (RWD) set, based on single central retinal fundus images of diabetic eyes from different origins, with the aim of validating its use as a precision tool for classifying diabetic retinopathy (DR) severity. Retrospective meta-analysis across multiple fundus image datasets. The study analyzed 2445 retinal fundus images from diabetic patients across four diverse RWD international datasets, including populations from Spain, India, China and the US.
View Article and Find Full Text PDFComparison of retinal vascular abnormalities in the fellow eyes of children with Coats' disease and normal subjects using ultra-widefield fundus fluorescein angiography.
Photodiagnosis Photodyn Ther
December 2024
Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China; Beijing Ophthalmology and Visual Science Key Laboratory, Beijing 100730, China. Electronic address:
Purpose: To investigate retinal vascular abnormalities in the affected and fellow eyes of children with Coats' disease using Optos® ultra-widefield fundus fluorescein angiography (UWFFA) and compare the peripheral vascular abnormalities between fellow eyes and normal control eyes.
Methods: Children diagnosed with Coats' disease who underwent UWFFA were retrospectively reviewed. Healthy eyes with complete UWFFA data were selected as controls.
Pro Re Nata brolucizumab for early onset and treatment-naïve diabetic macular edema: A prospective study.
Eur J Ophthalmol
August 2024
Department of Ophthalmology, Centre Hospitalier Universitaire de la Croix-Rousse, Hospices Civils de Lyon, 69004 Lyon, France.
Objectives: To determine the efficacy and safety of brolucizumab therapy administered on a (PRN) basis without loading dose in treatment naïve patients with diabetic macular edema (DME) for 1 year follow-up.
Methods: Patients with recent DME (<6 months) received a mandatory brolucizumab injection at inclusion and other injections could be given on a PRN basis with an 8-week interval (between injections) at minimum. Rescue therapy with other anti-VEGF was possible in case of incomplete DME resolution after the second brolucizumab with a minimum of 1-month treatment free interval between 2 injections.
Distribution of Microaneurysms and Hemorrhages in Accordance with the Grading of Diabetic Retinopathy in Type Diabetes Patients.
Diagnostics (Basel)
July 2024
Ophthalmology Service, Hospital Universitario Sant Joan, Universitat Rovira & Virgili, Institut de Investigacio Sanitaria Pere Virgili (IISPV), 43204 Reus, Spain.
(1) Underlying Diabetic Retinopathy (DR) is the primary cause of poor vision in young adults. There are automatic image reading systems that can aid screening for DR. (2) Methods: Using our automatic reading system we have counted the number of microaneurysms and hemorrhages in the four quadrants of the ETDRS grid and evaluated the differences between them according to the type of DR.
View Article and Find Full Text PDFSARS-CoV-2 infects cells lining the blood-retinal barrier and induces a hyperinflammatory immune response in the retina via systemic exposure.
PLoS Pathog
April 2024
Department of Ophthalmology, Mason Eye Institute, University of Missouri School of Medicine, Columbia, Missouri, United States of America.
SARS-CoV-2 has been shown to cause wide-ranging ocular abnormalities and vision impairment in COVID-19 patients. However, there is limited understanding of SARS-CoV-2 in ocular transmission, tropism, and associated pathologies. The presence of viral RNA in corneal/conjunctival tissue and tears, along with the evidence of viral entry receptors on the ocular surface, has led to speculation that the eye may serve as a potential route of SARS-CoV-2 transmission.
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