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Secondary insults prevalence, co-occurrence and relationship with outcome after severe TBI.
Brain Spine
February 2024
Brain Physics Laboratory Division of Neurosurgery Department of Clinical Neurosciences, University of Cambridge, UK.
Introduction: Secondary insults due to high intracranial pressure (ICP), low cerebral perfusion pressure (CPP) and impaired cerebral pressure reactivity (PRx) predict outcome after severe traumatic brain injury (TBI).
Research Question: What is the prevalence, co-occurrence and prognostic importance of secondary insults due to deranged ICP, CPP or PRx after TBI.
Material And Methods: Severe TBI patients requiring ICP monitoring were included.
Gas and vapor phase detection of chemical threats on cooled SERS substrates.
Talanta
December 2024
Center for Intelligent Drug Delivery and Sensing Using Microcontainers and Nanomechanics (IDUN), Department of Health Technology, Technical University of Denmark, Kgs. Lyngby, 2800, Denmark.
Detection of airborne chemical threats is an emerging challenge amidst the prevailing tumultuous global milieu. Extensive investigation has showcased the substantial promise of surface-enhanced Raman spectroscopy (SERS) for the on-site identification of hazardous chemicals present in liquid mediums, whether directly from a fluid source or through methodologies such as swab sampling. Nonetheless, exploration into the applicability of SERS for the detection of gas or vapor-phase chemical threats remains severely constrained.
View Article and Find Full Text PDFDefining the optimal radiation-induced lymphopenia metric to discern its survival impact in esophageal cancer.
Int J Radiat Oncol Biol Phys
January 2025
Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston TX, United States of America; Department of Radiation Oncology, Amsterdam UMC, Amsterdam, The Netherlands.
Background: A detrimental association between radiation-induced lymphopenia (RIL) and oncologic outcomes in esophageal cancer patients has been established. However, an optimal metric for RIL remains undefined, but is important for application of this knowledge in clinical decision-making and trial designs. The aim of this study was to find the optimal RIL metric discerning survival.
View Article and Find Full Text PDFAntidepressants and Weight Gain: An Update on the Evidence and Clinical Implications.
Curr Obes Rep
January 2025
Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, 21224, USA.
Purpose Of Review: To highlight recent research on antidepressant use and weight change and explore best clinical practices for reducing weight gain and obesity risk in individuals with depression.
Recent Findings: Research on antidepressant use and weight gain suggests that genetic and biological factors including metabolizer phenotypes and inflammation can help to predict an individual's threshold for weight change among specific agents. For individuals with increased susceptibility to metabolic complications, medications including bupropion, fluoxetine, and newer agents (e.
Forward-backward translation, content validity, face validity, construct validity, criterion validity, test-retest reliability, and internal consistency of a questionnaire on patient acceptance of orthodontic retainer.
PLoS One
January 2025
Department of Paediatric Dentistry and Orthodontics, Faculty of Dentistry, Universiti Malaya (UM), Kuala Lumpur, Malaysia.
This study aimed to assess the validity and reliability of a questionnaire on patient acceptance of orthodontic retainers. The original questionnaire was forward- and backward-translated, followed by four validity tests (content validity, face validity, construct validity, criterion validity) and two reliability tests (test-retest reliability, internal consistency). Content validity was assessed by nine orthodontists who appraised the questionnaire's representativeness, relevance, clarity, and necessity.
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