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| http://dx.doi.org/10.1056/NEJMc1411954 | DOI Listing |
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The Determinants of Long-Term Outcomes After Colorectal Cancer Surgery: A Literature Review.
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Emergency Department, Sandwell and West Birmingham NHS Trust, Birmingham, GBR.
Colorectal cancer (CRC) is a common malignancy associated with high mortality. Surgical care is an effective colorectal cancer management technique, and it is therefore crucial that a review of the determinants of patients' long-term outcomes after CRC surgery is conducted. This article aims to provide healthcare professionals and policymakers with insights into the determinants of long-term outcomes following CRC surgery while acknowledging the interconnected impact of the early recovery and post-operative periods.
View Article and Find Full Text PDFLaparoscopic surgery is associated with increased risk of postoperative peritoneal metastases in T4 colon cancer: a propensity score analysis.
Int J Colorectal Dis
January 2025
Department of Colorectal Surgery, the First Affiliated Hospital of Naval Medical University, Shanghai, 200433, China.
Background: This study aims to evaluate the postoperative safety, long-term survival, and postoperative peritoneal metastases (PPM) rate associated with laparoscopic surgery (LS) for T4 colon cancer.
Materials And Methods: After propensity score matching, there were 68 patients in each of the LS and Open surgery groups. The primary outcomes were the 3-year OS, DFS, and PPM rates.
A 3D bioprinted potential colorectal tumor model based on decellularized matrix/gelatin methacryloyl/nanoclay/sodium alginate hydrogel.
Int J Biol Macromol
December 2024
Cancer Hospital of Dalian University of Technology, State Key Laboratory of Fine Chemicals, Dalian R&D Center for Stem Cell and Tissue Engineering, Dalian University of Technology, Dalian 116024, China. Electronic address:
Colorectal cancer (CRC) is now the third most common cancer worldwide. However, the development cycle for anticancer drugs is lengthy and the failure rate is high, highlighting the urgent need for new tumor models for CRC-related research. The decellular matrix (dECM) offers numerous cell adhesion sites, proteoglycan and cytokines.
View Article and Find Full Text PDFComparison of Cell-death Kinetics of Recombinant Methioninase (rMETase)-treated Cancer and Normal Cells: Only Cancer Cells Undergo Methionine-depletion Catastrophe at Low rMETase Concentrations.
Anticancer Res
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AntiCancer Inc., San Diego, CA, U.S.A.;
Background/aim: Methionine addiction, known as the Hoffman effect, makes cancer cells more sensitive to methionine restriction than normal cells. However, the long-term effects of methionine restriction on cancer and normal cells have not been thoroughly studied.
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Achieving Health Equity: Advancing Colorectal Surgery among Racial and Ethnic Minorities in America.
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January 2025
Division of Gastrointestinal Surgery, Department of General Surgery, University of Alabama at Birmingham, Birmingham, Alabama.
Racial inequities in short and long-term outcomes following colorectal surgery continue to persist. Using inflammatory bowel disease and colorectal cancer as disease foci, we review existing racial inequities in surgical outcomes and complications, discuss how social determinants of health and biopsychosocial factors can contribute to these inequities, and highlight potential mechanisms for building interventions to achieve health equity following colorectal surgery for minority populations.
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