AI Article Synopsis
- BRAF inhibitors, commonly used for metastatic melanoma with BRAF mutations, can cause skin side effects like keratoacanthomas and squamous cell carcinomas.
- A patient treated with vemurafenib developed multiple epidermal cysts within 2 months, specifically in the area of a previously irradiated melanoma tumor.
- These localized cysts may represent a rare reaction, possibly termed a radiation recall, in patients receiving BRAF inhibitors.
Article Abstract
BRAF inhibitors are broadly used for metastatic melanoma with BRAF mutations. Their use results in various cutaneous side effects, such as the development of keratoacanthomas and squamous cell carcinomas. We report a patient with metastatic melanoma treated with vemurafenib who developed dozens of histologically confirmed epidermal cysts within 2 months after initiation of vemurafenib administration. The cystic lesions were observed only in the localized area where a large exophytic melanoma tumor mass had been previously irradiated. Localized epidermal cysts may constitute an unusual radiation recall reaction in patients treated with BRAF inhibitors.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4209266 | PMC |
| http://dx.doi.org/10.1159/000367708 | DOI Listing |
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