Mild Ti-mediated transformation of t-butyl thio-ethers into thio-acetates.

Org Biomol Chem

Zernike Institute for Advanced Materials, University of Groningen, Nijenborgh 4, 9747 Groningen, The Netherlands.

Published: January 2015

We report a straightforward method for the rapid conversion of thio-ethers to thio-acetates using TiCl4, in good to excellent yields. The reaction conditions tolerate a variety of functional groups, including halide, nitro, ether, thiophene and acetylene functionalities. A catalytic variant of this reaction is also described.

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Source
http://dx.doi.org/10.1039/c4ob02120gDOI Listing

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