AI Article Synopsis
- Dowling-Degos disease is a rare skin condition characterized by the development of clusters of papules and reticulate macules, primarily in areas like the armpits and groin.
- It is caused by mutations in the keratin 5 gene and can occur sporadically or in an autosomal dominant pattern.
- The case report focuses on an elderly man whose Dowling-Degos disease presented with multiple seborrheic keratoses arranged in a "Christmas tree" pattern, which evolved over more than 30 years.
Article Abstract
Dowling-Degos disease is a rare sporadic or autosomal dominant pigmentary entity, in which clusters of papules and reticulate macules slowly develop with predominance in flexural regions. This entity is due to mutations in the keratin 5 gene, and is related with other cutaneous disorders. We report the sporadic form of Dowling-Degos disease in an elderly man with multiple seborrheic keratosis in a "Christmas tree" pattern. Worthy of note in this case study is the lesions evolved for over than 30 years. The aim is to describe the association of these keratoses with Dowling-Degos disease in a healthy man.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4219898 | PMC |
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