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| http://dx.doi.org/10.11604/pamj.2014.18.126.4007 | DOI Listing |
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Radiographs in Pediatric Rheumatology: Where Do We Stand?
Indian J Radiol Imaging
January 2025
Division of Paediatric Rheumatology, Department of Paediatrics, All India Institute of Medical Sciences, New Delhi, India.
Rheumatic disorders in children include inflammatory arthritis, inflammatory bone disorders such as chronic nonbacterial osteomyelitis (CNO), connective tissue disorders, and vasculitides (juvenile dermatomyositis, scleroderma). The diagnosis in these children is based on a combination of history, clinical examination, and laboratory investigations. Radiographs play an important role in children with arthritis, who have atypical presentation or for assessment of disease-related damage and differentiation from mimics.
View Article and Find Full Text PDFGenetic Diagnosis and Prenatal Diagnosis of a Rare FVIII Family With Haemophilia A.
J Cell Mol Med
December 2024
Reproductive Genetics Department, Hebei General Hospital, Shijiazhuang, Hebei, China.
Article Synopsis
- - The study focused on identifying genetic variations causing haemophilia A within a unique family, using advanced techniques like DHPLC and PCR for diagnosis.
- - Comprehensive clinical data and laboratory tests revealed the proband's significantly prolonged activated partial prothrombin time (APTT) and low clotting factor VIII activity, suggesting serious coagulation issues.
- - A rare pathogenic mutation involving a 226 bp insertion in the F8 gene was discovered, highlighting the importance of using multiple experimental approaches for effective genetic diagnosis of haemophilia A.
The Utility of Total Thrombus-Formation Analysis System (T-TAS) in the Thrombosis and Hemostasis Field: A Scoping Review.
Int J Lab Hematol
December 2024
CARIM-School for Cardiovascular Disease, Maastricht University, Maastricht, The Netherlands.
Background: A wide variety of laboratory hemostasis tests is available, but the majority is plasma-based, static and unable to assess platelet function and fibrin formation simultaneously. The Total Thrombus-Formation Analysis System (T-TAS) is a microchip-based flow chamber system that simulates in vivo conditions for evaluating whole blood thrombogenicity.
Aim: A comprehensive overview of its applicability in different thrombosis and hemostasis related clinical situations is lacking and therefore this scoping review was performed.
Looking Beyond Thrombocytopenia for Bleeding in a Case of Dengue Fever: From Dengue to Hemophilia C.
Cureus
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Internal Medicine, Max Smart Super Speciality Hospital, New Delhi, IND.
Article Synopsis
- * A case study details a young man in his early twenties who was hospitalized for Dengue, experiencing dark stools (melena) and vomiting blood.
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The efficacy and application of tranexamic acid in emergency medicine: Emergency Medicine Association of Türkiye clinical policy- 2024.
Turk J Emerg Med
October 2024
Department of Medical Education, Acibadem Mehmet Ali Aydınlar University, School of Medicine, Istanbul, Türkiye.
The clinical policy of the Emergency Medicine Association of Türkiye (EMAT) provides guidance on the use of tranexamic acid (TXA) in emergency settings. TXA, an antifibrinolytic drug, is used to control bleeding by inhibiting plasminogen. Its applications have expanded from hemophilia and severe menstrual bleeding to include various forms of trauma and surgery-related bleeding.
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