14,620 sets of patient dose data were obtained for 31 different models of computed tomography (CT) equipment (total 73) with 18 types of CT examination in Korea. Specific diagnostic reference levels (DRLs) for this study in terms of third quartile volumetric CT dose index in mGy [and dose-length product (DLP) in mGy.cm] are as follows: head, 53 (910); neck, 20 (770); chest, 14 (710); abdomen, 14 (1000); stomach, 14 (1000); liver, 14 (1700); pancreas, 14 (1700); kidney, 14 (2100); cervical spine, 30 (600); lumbar spine, 25 (760); hip, 17 (600); cardiac CT angiography, 45 (1250); head CT angiography, 43 (1900); liver CT angiography, 14 (1400) and thoraco-abdominal CT angiography, 16 (2000). In the present study, DRLs in terms of volumetric CT dose index were below previously published reference levels, partly because the newer CT equipments have improved technology that facilitates lower patient dose. Meanwhile, DRLs in terms of DLP were higher, because multi-phase scanning protocols with prolonged scan coverage have been widely used.
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http://dx.doi.org/10.1093/rpd/ncu293 | DOI Listing |
Curr Drug Saf
January 2025
Department of Chemistry, K J Somaiya College of Science and Commerce, Vidyavihar, Mumbai-77, India.
The presence of N-nitrosamine impurities in pharmaceutical products is well known. In 2019, it resulted in drug recall by the Food and Drug Administration (FDA). Soon, several groups identified the presence of many N-nitrosamines (NAs) in various Active Pharmaceutical Ingredients (APIs) and drug formulations worldwide.
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Department of Pediatrics, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, Henan, China.
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The Hatter Cardiovascular Institute, University College London, 67 Chenies Mews, London, WC1E 6HX, UK.
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We describe the utility of 'folic and folinic acid load tests' in the investigation of a 26-year-old woman with persistently low serum folate and moderate hyperhomocysteinaemia unresponsive to folic acid supplements. Serum folate, plasma 5-methyltetrahydrofolate (5-MTHF), red cell 5-MTHF and plasma total homocysteine at baseline, 2-h, 4-h and 2- or 4-days (if applicable) post administration of a large dose of oral folic acid, or oral or parenteral folinic acid were measured. The tests confirmed non-compliance but also suggested an unsuspected possible defect in the folate pathway based on differential response to folic versus folinic acid supplements.
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Department of Pharmacy, The Fourth Affiliated Hospital of Soochow University, Suzhou Dushu Lake Hospital, Medical Center of Soochow University, Suzhou, 215123, China.
1. Polymorphisms in genes related to drug-metabolizing genes may affect tacrolimus exposure. This study aimed to assess the influence of , , and polymorphisms on tacrolimus pharmacokinetics and outcomes in allogeneic hematopoietic stem cell transplantation (HSCT).
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