Dynamics of double strand breaks and chromosomal translocations.

Mol Cancer

UMR8126, Université Paris-Sud, CNRS, Institut de cancérologie Gustave Roussy, Villejuif 94805, France.

Published: November 2014

AI Article Synopsis

  • Chromosomal translocations are significant contributors to the development of cancer.
  • The specific processes that cause these translocations between different gene regions are not well understood.
  • The review highlights recent findings on how double strand breaks (DSBs) in DNA are generated, move, and are repaired, emphasizing the role of nuclear organization in these events.

Article Abstract

Chromosomal translocations are a major cause of cancer. At the same time, the mechanisms that lead to specific chromosomal translocations that associate different gene regions remain largely unknown. Translocations are induced by double strand breaks (DSBs) in DNA. Here we review recent data on the mechanisms of generation, mobility and repair of DSBs and stress the importance of the nuclear organization in this process.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4289179PMC
http://dx.doi.org/10.1186/1476-4598-13-249DOI Listing

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