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In Vitro Activity of Ampicillin Plus Ceftriaxone Against Non- and Non- Enterococcal Isolates With/Without VanC Phenotype: Clinical Implications for Infective Endocarditis.
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December 2024
Infectious Diseases Service, Hospital Clínic, Fundació de Recerca Clínic Barcelona-Institut d'Investigacions Biomèdiques August Pi i Sunyer, University of Barcelona, 08036 Barcelona, Spain.
(1) Background: Alternative antibiotics are needed to treat infective endocarditis (IE) caused by non-/non- enterococci; we aimed to assess the in vitro activity of ampicillin plus ceftriaxone (AMP + CTR) against these enterococci and to describe its clinical efficacy in IE cases. (2) Methods: Time-kill curves with standard (ISI) and high (IHI) inocula were performed to test isolates [3 (ECAS) and 1 (EGALL)] and non- isolates [1 (EDUR), 1 (EHIR) and 1 (ERAF)]. The narrative literature review of IE cases treated with AMP + CTR was analyzed alongside three study cases.
View Article and Find Full Text PDFCombined Antibiotic and Photodynamic Therapies in : From Synergy to Antagonism.
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November 2024
Biomedical Engineering, Texas A&M University, College Station, TX 77843, USA.
Antibiotics remain the most effective option for combating infections. However, the situation has shifted from ideal to concerning, as bacterial resistance to antibiotics is increasing in both prevalence and strength. : This study explores the synergistic/antagonistic potential of combining antibiotic and photodynamic therapy (PDT) against .
View Article and Find Full Text PDFTranscatheter aortic valve implantation (TAVI) prostheses - biofilm formation and antibiotic effects.
Biofilm
December 2024
Department of Clinical Microbiology, Rigshospitalet Copenhagen University Hospital, Copenhagen, Denmark.
Background: Transcatheter aortic valve implantation (TAVI) is a percutaneous catheter-based treatment of aortic stenosis as an alternative to open heart valve surgery. In cases of TAVI endocarditis, the treatment possibilities may be limited as surgical removal of the infected valve may be associated with a high risk in elderly, comorbid or frail patients. The propensity of bacteria to form a biofilm on foreign material is assumed to be of importance part of the disease process in TAVI endocarditis, but no studies on biofilm formation on TAVI valves have been conducted.
View Article and Find Full Text PDFSelenomethionine Mitigates Effects of Induced Inflammation, Oxidative Stress, and Apoptosis in Bovine Mammary Epithelial Cells.
Int J Mol Sci
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College of Veterinary Medicine, China Agricultural University, Beijing 100193, China.
causes bovine mastitis, reduces milk quantity and quality, and is often resistant to antimicrobials. Selenomethionine (SeMet) is a form of selenium, which reduces reactive oxygen species (ROS)-mediated apoptosis and intramammary infections. However, the protective effects of SeMet on -infected bovine mammary epithelial cells (bMECs) are unclear.
View Article and Find Full Text PDFperformance of cost differentiated ceftriaxone brands against : insights from a tertiary referral hospital in Mbeya, Tanzania.
JAC Antimicrob Resist
October 2024
Research Unit, Mbeya Zonal Referral Hospital, P. O. Box 419, Mbeya, Tanzania.
Background: In Tanzania, ceftriaxone is one of the most commonly prescribed antibiotics. However, there is quite a significant variation in cost for numerous ceftriaxone brands, leading to the perception that pricier options are more effective. Yet, limited empirical data support this perception.
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