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Baclofinding solutions: Baclofen-induced encephalopathy in a peritoneal dialysis patient.
Perit Dial Int
January 2025
Department of Medicine, Johns Hopkins Aramco Healthcare Center, Dhahran, Saudi Arabia.
Baclofen is a gamma-aminobutyric acid agonist that is commonly and widely used for the treatment of muscle spasticity. Given its predominant kidney excretion, patients with reduced kidney function are at particular risk of drug accumulation and toxicity, with neurotoxicity in the form of drowsiness, encephalopathy, seizures, and coma being the most reported clinical features. In addition to the importance of early identification of baclofen toxicity and drug discontinuation, dialysis can effectively accelerate baclofen elimination given its small molecule weight, and the relatively low volume of distribution and weak protein binding.
View Article and Find Full Text PDFPharmacovigilance insights into medication-induced risk of dural arteriovenous fistula.
Int J Surg
January 2025
Department of Orthopedics, Civil Aviation General Hospital, Beijing, China.
Background: Dural arteriovenous fistulas (DAVFs) pose a significant health threat owing to their high misdiagnosis rate. Case reports suggest that DAVFs or related acute events may follow medication use; however, drug-related risk factors remain unclear. In clinical practice, the concomitant use of multiple drugs for therapy is known as "polypharmacy situations," further increasing the risk of drug-induced DAVF.
View Article and Find Full Text PDFThe Use of Baclofen to Control Vertical Nystagmus in a Patient with Advanced Glioma: A Case Report.
J Hosp Palliat Care
December 2024
Department of Palliative Care, Comprehensive Cancer Center, King Fahad Medical City, Riyadh, SAU.
Nystagmus, characterized by involuntary eye movements, can arise from several causes, with benign paroxysmal positional vertigo being the most prevalent. Additionally, central lesions such as tumors may also induce nystagmus. This case report describes the amelioration of vertical nystagmus in a patient with advanced glioma after treatment with the GABAergic drug baclofen.
View Article and Find Full Text PDFRole of Rab10 in cocaine-induced behavioral effects is associated with GABAB receptor membrane expression in the nucleus accumbens.
Front Pharmacol
November 2024
Department of Pathophysiology, School of Basic Medical Sciences, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, China.
Aim: Previous studies have demonstrated that Ras-related GTP-binding protein Rab10 (Rab10) plays a role in psychostimulant-induced behavioral effects. In this study, we showed that Rab10 in the nucleus accumbens (NAc) of male animals affects the development of cocaine-induced behavioral effects, which are associated with the plasma membrane expression of the GABA heteroreceptor (GABAR).
Methods: We performed flow cytometry, immunoendocytosis, pHluorin activity analysis, electrophysiology analysis, and open-field testing to explore the role of Rab10 in modulating the membrane expression and function of GABAR and its regulatory effect on cocaine-induced behavioral effects.
Drug-induced Liver Injury Due to Medications for Alcohol Use Disorder: Results From the DILIN Prospective Study.
J Addict Med
December 2024
From the Liver Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD (HG, CK); Division of Gastroenterology and Hepatology, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN (MG, NC); Department of Biostatistics and Bioinformatics, Duke Clinical Research Institute, Duke University, Durham, NC (JG, YJL); Division of Gastroenterology and Hepatology, University of Michigan, Ann Arbor, MI (RJF); and Laboratory of Pathology, Intramural Division, National Cancer Institute, National Institutes of Health, Bethesda, MD (DEK).
Objectives: Concerns about drug-induced liver injury (DILI) may deter physicians from prescribing medications for alcohol use disorder (MAUD). We aim to explore DILI due to MAUD in Drug-Induced Liver Injury Network (DILIN) prospective study.
Methods: High-confidence DILI cases (ie, definite, highly likely, or probable) due to MAUD in DILIN prospective study (2004-2024) were included.
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