AI Article Synopsis

  • A 60-year-old man with Behçet's disease and myelodysplastic syndrome underwent cord blood transplantation (CBT) with anti-thymocyte globulin and tacrolimus to avoid graft-versus-host disease.
  • Two months post-transplant, his tacrolimus (Tac) levels were erroneously reported as greater than four times higher than normal, despite treatment being stopped.
  • This false reading was linked to interference from endogenous heterophilic antibodies affecting the antibody-conjugated magnetic immunoassay (ACMIA), emphasizing the need for caution in interpreting results for patients with autoimmune conditions.

Article Abstract

We herein describe the case of a 60-year-old man with a history of Behçet's disease and myelodysplastic syndrome who received cord blood transplantation (CBT). The patient was given anti-thymocyte globulin conditioning and tacrolimus to prevent graft-versus-host disease. Two months after CBT, his blood Tac concentration measured by an antibody-conjugated magnetic immunoassay (ACMIA) was found to have increased >4-fold, even after the Tac treatment was stopped. This false response was caused by the interference of endogenous heterophilic antibodies with ACMIA. Therefore, physicians must be aware of possible false ACMIA results for patients with a history of autoimmune disease and/or treated by xenogeneic antibody therapy.

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http://dx.doi.org/10.2169/internalmedicine.53.2170DOI Listing

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