Decline of semen quality due to endocrine-disrupting chemicals is of concern globally. Among endocrine disrupting chemicals (EDC), Polychlorinated biphenyls (PCB) are associated with reduced semen quality in various epidemiological studies. In this study, we evaluated the direct effects of selected PCBs (28, 30 and 118) on fresh spermatozoa of Simmetial bulls aged 2-4 years were evaluated in vitro by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay and computer assisted semen analysis (CASA) (SCA; Microptics) analysis. IC50 values were found as 8.45, 5.45 and 9.55 ng/ml for PCB 28, 30 and 118, respectively. Total motility, progressive motility and viability decreased dependent on dose and duration of exposure (0, 2, 4 h). Total motility at IC50 doses decreased the most in PCB 28 (72.24%) followed by 30 (60.75%) and 118 (64.77%) at 2nd hour following exposure. Motility results were found to be in accordance with the vitality and morphology data where total abnormalities (especially reacted acrosome rate) were found to have increased.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1111/rda.12447 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Updated Mini-Review on Polychlorinated Diphenyl Ethers (PCDEs) in Food: Levels and Dietary Intake.
J Food Prot
January 2025
Universitat Rovira i Virgili Laboratory of Toxicology and Environmental Health, School of Medicine, 43201, Reus, Catalonia, Spain. Electronic address:
Polychlorinated diphenyl ethers (PCDEs) are a class of chlorinated aromatic compounds with structural similarities to polychlorinated biphenyls (PCBs) and polychlorinated dibenzo-p-dioxins/dibenzofurans (PCDD/Fs). Due to their physicochemical properties, PCDEs are highly resistant to degradation and tend to accumulate in soils, sediments, and aquatic organisms, making them capable of entering and persisting in the food chain. As with other persistent organic pollutants (POPs), diet represents the primary route of human exposure to PCDEs.
View Article and Find Full Text PDFContaminant-Associated Disruption of the Skin Transcriptome in the Endangered St. Lawrence Estuary Beluga.
Environ Sci Technol
January 2025
Fisheries and Oceans Canada, Pacific Science Enterprise Center, 4160 Marine Drive, West Vancouver, British Columbia V7V 1N6, Canada.
The St. Lawrence Estuary (SLE) beluga () population in Canada is Endangered, and endocrine disrupting contaminants, such as polychlorinated biphenyls (PCBs), polybrominated diphenyl ethers (PBDEs), and other halogenated flame retardants, have been identified as a threat to the recovery of this population. Here, potential impacts of these contaminants on SLE beluga were evaluated by comparing skin transcriptome profiles and biological pathways between this population and a population less exposed to contaminants (Eastern Beaufort Sea) used as a reference.
View Article and Find Full Text PDFCurrent level, sources, and risk of human exposure to PAHs, PBDEs and PCBs in South American outdoor air: A critical review.
Environ Res
January 2025
Institute of Science and Technology, São Paulo State University (UNESP), Av. Três de Março, 511, Alto da Boa Vista, 18087-180 Sorocaba, SP, Brazil. Electronic address:
This study provides comprehensive overview of the current level, sources and human exposure risk to hazardous polycyclic aromatic hydrocarbons (PAHs), polybrominated diphenyl ethers (PBDEs), and polychlorinated biphenyls (PCBs) in South American outdoor air. Research documents were obtainable for only 6 countries within the target period (2014 - 2024). For all contaminants, urban concentrations exceeded that of rural/remote locations.
View Article and Find Full Text PDFTreatment of polycyclic aromatic hydrocarbons (PAHs) and polychlorinated biphenyls (PCBs) in stormwater using polishing columns with biochar and granular activated carbon.
Chemosphere
January 2025
Department of Civil and Environmental Engineering, University of Maryland, College Park, MD, 20742, USA. Electronic address:
Polycyclic Aromatic Hydrocarbons (PAHs) and Polychlorinated Biphenyls (PCBs) are recalcitrant organic pollutants often detected in stormwater. Various stormwater control measures (SCMs) can remove PAHs and PCBs by filtration, adsorption, and biodegradation. However, dissolved PAHs and PCBs remain present in the treated outflow of SCMs.
View Article and Find Full Text PDFTissue bioaccumulation and distribution of organic contaminants in Brazilian guitarfish Pseudobatos horkelii reveal a concerning impact of contraceptive hormones and fecal sterols.
Mar Pollut Bull
January 2025
Instituto de Ciências Biológicas, Universidade Federal do Rio Grande - FURG, Rio Grande, RS, Brazil. Electronic address:
The critically endangered Brazilian guitarfish faces significant threats from environmental contamination. Assessing the impacts of such stressor is paramount from a conservational perspective. This study investigated the concentrations, distribution and accumulation patterns of organic contaminants in pregnant Brazilian guitarfish Pseudobatos horkelii.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!