AI Article Synopsis
- A study investigated the relationship between cyclin D1 polymorphism and the risk of developing breast cancer, as previous research showed mixed results.
- After analyzing data from 18 publications through odds ratios and confidence intervals, the study found no significant association between the polymorphism and breast cancer risk in any genetic model.
- The conclusions were consistent across different factors like ethnicity, control sources, and sample sizes, suggesting that cyclin D1 polymorphism likely does not increase susceptibility to breast cancer.
Article Abstract
Cyclin D1 polymorphism has been reported to be associated with risk of breast cancer, but the published studies have yielded controversial results. This study was undertaken to derive a precise risk estimate for the cyclin D1 polymorphism associated with breast cancer risk. We performed a search of EMBASE, PubMed, and Web of Science. In total, data from 18 publications were pooled and the association was assessed by odds ratios (ORs) with 95 % confidence intervals (CIs). This analysis showed that there was no obvious association between the cyclin D1 polymorphism and breast cancer risk in any of the analyzed genetic model. We found the same negative association in stratified analyses by ethnicity, source of controls, and sample size. Our meta-analysis provides an estimate that the presence of cyclin D1 polymorphism may not confer susceptibility to breast cancer.
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| http://dx.doi.org/10.1007/s13277-014-2489-5 | DOI Listing |
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