Background: Waist circumference (WC) to height ratio (WC/HT) is used as a measure of central obesity. However, the optimum ratio that will separate populations with high from low cardiovascular risk remains controversial. This investigation evaluates an optimum WC/HT value to define central obesity in children.
Methods: The sensitivity and specificity of WC/HT in 649 children (age 2-18 years) without evidence of heart disease were analyzed for WC and for body mass index (BMI).
Results: A WC/HT ≥0.5 resulted in sensitivity:specificity of 99%:72% for detecting central obesity and 83%:77% for detecting overweight (BMI ≥85th percentile) subjects. A value of WC/HT ≥0.55 yielded sensitivity:specificity of 80%:96% for detecting central obesity and 75%:94% for detecting subjects with obesity (BMI ≥95th percentile).
Conclusions: The use of WC/HT between ≥0.5 and <0.55 identified subjects at-risk for central obesity and WC/HT ≥0.55 identified central obesity with a high probability.
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http://dx.doi.org/10.1177/0009922814557784 | DOI Listing |
Eur J Pharmacol
January 2025
Pharmacology Division, CSIR-Central Drug Research Institute, Lucknow 226031, India; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad- 201002, India. Electronic address:
Obesity and its associated metabolic disorders are significant global health challenges, necessitating novel therapeutic approaches. This study explores the anti-adipogenic and anti-dyslipidemic properties of 4655-EF, a novel phytopharmaceutical derived from Polyalthia longifolia, and explores the molecular pathways involved in its pharmacological activity. This phytopharmaceutical was prepared using a bioactivity-guided supercritical fluid extraction method suitable for large-scale production.
View Article and Find Full Text PDFEnviron Int
January 2025
Helmholtz Institute for Metabolic, Obesity and Vascular Research (HI-MAG) of the Helmholtz Centre München at the University of Leipzig Germany; Department of Endocrinology Nephrology Rheumatology University Hospital Leipzig Medical Research Center Leipzig Germany.
Plastic materials are ubiquitous, leading to constant human exposure to plastic additives such as plasticizers. There is growing evidence that plasticizers may contribute to obesity due to their disruptive effects on metabolism. Alternatives like diisononylcyclohexane-1,2-dicarboxylate (DINCH) are replacing traditional phthalates such as di-(2-ethylhexyl) phthalate (DEHP), which are now banned due to their proven harmful health effects.
View Article and Find Full Text PDFJ Clin Anesth
January 2025
Department of Anaesthesiology, The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangdong Clinical Research Academy of Chinese Medicine, Guangzhou, China. Electronic address:
Study Objective: Difficult airway management is a significant challenge in clinical anesthesia, critical care, and emergency medicine. Inadequate management can lead to severe complications including organ damage and death. This study assessed the variability in difficult airway management across China and focused on how patient and operator factors influenced outcomes in operating rooms.
View Article and Find Full Text PDFOrthopadie (Heidelb)
January 2025
Klinik für Orthopädie, Unfall- und Handchirurgie, HELIOS Klinikum Krefeld, Lutherplatz 40, 47805, Krefeld, Deutschland.
Background: Obesity is increasingly being recognized as a significant risk factor for the development and worsening of back pain. In order to make possible adjustments to therapies and lifestyle, the relationship must first be understood.
Method: This article attempts to explain the relationship between obesity and back pain based on the existing literature.
Cochrane Database Syst Rev
January 2025
Cornell Joan Klein Jacobs Center for Precision Nutrition and Health, Cornell University, Ithaca, NY, USA.
Background: Precision nutrition-based methods develop tailored interventions and/or recommendations accounting for determinants of intra- and inter-individual variation in response to the same diet, compared to current 'one-size-fits-all' population-level approaches. Determinants may include genetics, current dietary habits and eating patterns, circadian rhythms, health status, gut microbiome, socioeconomic and psychosocial characteristics, and physical activity. In this systematic review, we examined the evidence base for the effect of interventions based on precision nutrition approaches on overweight and obesity in children and adolescents to help inform future research and global guidelines.
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