Although corneal allotransplantation is performed in the immune-privileged cornea, many grafts are still rejected after transplantation. This study examined the role of chemokine receptor D6 expression in a corneal allograft rejection, investigated the modulation of D6 expression in cells, and determined the effect of D6 on graft survival. Interestingly, D6 was highly expressed in CD45 -: cells and the corneal epithelium of accepted corneal allografts. From the mouse corneal allograft model, TGF-β was found to play a key role in D6 up-regulation, leading to reduced CCL2, CCL5, and CCL3. To modulate D6 chemokine binding, a D6MT was developed and showed effective chemokine trapping through SPR and FACS assays. By treating corneal allografts with D6MT, the allograft survival rate was improved, and (lymph) angiogenesis was reduced. Direct allosensitization and DC LN homing was drastically reduced in the mouse corneal allograft model. These findings suggest that TGF-β is a positive regulator of D6 expression, and it is a potential therapeutic target to enhance the survival of corneal allografts.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1189/jlb.5A0414-233RR | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
The burden of medical contraindications to corneal donation: Time for review.
PLOS Glob Public Health
December 2024
Laboratory Biology, Engineering and Imaging for Ophthalmology, Health Innovation Campus, Faculty of Medicine, University Jean Monnet, Saint-Etienne, France.
Corneal graft (keratoplasty) is the most common allograft in the world, but the imbalance between the number of donors and the number of patients waiting for transplants is abysmal on a global scale and varies enormously from one country to another. The risk of transmission of systemic diseases from donor to recipient is demonstrably low. In over 50 years and an estimated 2.
View Article and Find Full Text PDFPostoperative corneal remodeling after corneal allograft intrastromal ring segment (CAIRS) implantation for keratoconus: An OCT study.
Indian J Ophthalmol
December 2024
Department of Ophthalmology, Swiss Vision Eye Group, Istanbul, Turkey.
Objectives: To demonstrate corneal remodeling after corneal allograft intrastromal ring segment (CAIRS) with an anterior-segment optical coherence tomography (AS-OCT).
Design: A prospective observational single-center study.
Methods: This observational study included keratoconus patients who underwent CAIRS implantation into a stromal tunnel.
Current and emerging strategies for the manufacture, implantation, and clinical management of corneal tissue allografts.
Clin Exp Optom
December 2024
Centre for Vision and Eye Research, Queensland University of Technology, Brisbane, Queensland, Australia.
Article Synopsis
- Over the past 40 years, around 40,000 Australians have undergone corneal transplants, primarily due to conditions like keratoconus and Fuchs' dystrophy, with increasing demand due to an aging population.
- The global shortage of donor corneas is significant, with demand exceeding supply by 70 times, particularly in less-developed countries, prompting advancements in tissue banking and surgical techniques.
- New strategies like organ culture for donor corneas, bespoke surgical methods, and cell culture technologies are improving tissue storage, reducing transplant requirements, and enhancing patient care for corneal conditions.
Advanced bioengineering strategies broaden the therapeutic landscape for corneal failure.
Front Bioeng Biotechnol
November 2024
Institute for Neurosciences of Montpellier, INSERM, University of Montpellier, Montpellier, France.
The cornea acts as the eye foremost protective layer and is essential for its focusing power. Corneal blindness may arise from physical trauma or conditions like dystrophies, keratitis, keratoconus, or ulceration. While conventional treatments involve medical therapies and donor allografts-sometimes supplemented with keratoprostheses-these options are not suitable for all corneal defects.
View Article and Find Full Text PDFPurpose: To compare and assess the visual, refractive, and tomographic results of patients with corneal ectasia treated with either corneal allogenic intrastromal ring segments (CAIRS) or synthetic intrastromal corneal ring segments (ICRS) without concomitant corneal cross-linking.
Methods: In this retrospective cohort study, 34 eyes with CAIRS were matched to 34 eyes with ICRS using the propensity score matching technique. Each group was matched on a oneto-one basis using multiple parameters such as central corneal thickness, vertical and horizontal coma, maximum anterior keratometry, steepest keratometry, and age.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!