The cardiovascular health of the human population is a major concern for medical clinicians, with cardiovascular diseases responsible for 48% of all deaths worldwide, according to the World Health Organization. The development of new diagnostic tools that are practicable and economical to scrutinize the cardiovascular health of humans is a major driver for clinicians. We offer a new technique to obtain seismocardiographic signals up to 54 Hz covering both ballistocardiography (below 20 Hz) and audible heart sounds (20 Hz upward), using a system based on curvature sensors formed from fiber optic long period gratings. This system can visualize the real-time three-dimensional (3-D) mechanical motion of the heart by using the data from the sensing array in conjunction with a bespoke 3-D shape reconstruction algorithm. Visualization is demonstrated by adhering three to four sensors on the outside of the thorax and in close proximity to the apex of the heart; the sensing scheme revealed a complex motion of the heart wall next to the apex region of the heart. The detection scheme is low-cost, portable, easily operated and has the potential for ambulatory applications.
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http://dx.doi.org/10.1117/1.JBO.19.11.117006 | DOI Listing |
Microvasc Res
January 2025
Primary Health Care Center, Department of Health, Medicine and Caring Sciences, Faculty of Medicine and Health Sciences, Linköping University, Linköping, Sweden; Wallenberg Centre for Molecular Medicine, Linköping University, Linköping, Sweden. Electronic address:
Introduction: Little is known about the day-to-day variability of different skin microcirculation parameters, and how this variability is influenced by age and sex. The aim was to examine the day-to-day variability of microcirculatory parameters in relation to age and sex.
Methods: The cutaneous microcirculation was measured using a fiber optic probe integrating laser Doppler flowmetry (LDF) and diffuse reflectance spectroscopy (DRS) to measure oxygen saturation, red blood cell (RBC) tissue fraction, speed-resolved and conventional perfusion.
Sci Rep
January 2025
Department of Ophthalmology, Federal University of São Paulo, São Paulo, SP, Brazil.
Chagas disease (CD), a parasitic infection, may have ocular repercussions in its cardiologic form, since a history of heart disease of other etiologies already has been established as a risk factor for neuropathies and maculopathies. The aim of the present study was to investigate preclinical structural and vascular optic nerve head (ONH) and macular parameters in patients with chronic CD. Nineteen patients with CD and 19 healthy subjects were evaluated with optical coherence tomography, optical coherence tomography angiography, and Laguna ONhE® software.
View Article and Find Full Text PDFBiosens Bioelectron
January 2025
Innovation Center of Functional Genomics and Molecular Diagnostics Technology of Gansu Province, Lanzhou, China.
Improving the sensitivity of biosensor has always the major challenge to measure lower detection concentration of biological samples. In this paper, a novel optical fiber surface plasmon resonance (SPR) biosensor based on TiC MXene/GNRs synergistically highly enhanced sensitivity was proposed. The TiC MXene and GNRs were coated on the optical fiber sensing probe by the electrostatic layer-by-layer (ELBL) assembly method.
View Article and Find Full Text PDFInt J Ophthalmol
January 2025
Department of Ophthalmology, Kasr ElAini Hospital, Cairo University, Cairo 1141, Egypt.
Aim: To compare the macular and optic nerve perfusion and vascular architecture using optical coherence tomography angiography (OCTA) in normal eyes of Egyptian (Caucasians) and South Asian (Asians) volunteers.
Methods: Cross-sectional analytical OCTA study performed on 90 eyes of South Asian (=45) and Egyptians (=45) were analyzed. All participants underwent best-corrected visual acuity test, slit lamp, and fundus examination.
Ophthalmology
January 2025
Eye Center, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Germany.
Purpose: To identify baseline clinical predictors of visual outcomes six months after acute optic neuritis using data from our completed clinical neuroprotection trial (TONE study).
Design: Secondary analysis of data from the TONE study cohort (NCT01962571).
Subjects: Total of 103 patients presenting within 10 days of a first episode of acute unilateral optic neuritis as a clinically isolated syndrome with baseline high contrast visual acuity (HCVA) < 20/40 Snellen (logMAR 0.
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