A cascade silver(I)-catalyzed hydroamination/Michael addition sequence has been developed to deliver highly substituted bicyclic guanidines. This transformation gives rise to geometrically and constitutionally stable ene-guanidines and generates a remote stereocenter with moderate to high diastereoselectivity.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4260634 | PMC |
| http://dx.doi.org/10.1021/ol502691w | DOI Listing |
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