The shelterin protein TRF2 has come to the limelight for its role in telomere maintenance and tumorigenesis. Herein, the application of rational design and synthesis allowed identifying the first TRF2TRFH binder able to elicit a marked DNA damage response in cancer cells. This work paves the way for the unprecedented employment of a chemical tool to finely tune specific mechanisms underlying telomere maintenance.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1021/ja5080773 | DOI Listing |
Publication Analysis
Top Keywords
telomere maintenance
8
shading trf2
4
trf2 recruiting
4
recruiting function
4
function horizon
4
horizon drug
4
drug development
4
development shelterin
4
shelterin protein
4
protein trf2
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!