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Dietary niacin intake and mortality among chronic kidney disease patients.
Front Nutr
November 2024
Department of Urology, Ningbo Mingzhou Hospital, Zhejiang, China.
Article Synopsis
- The study investigates the link between niacin intake and mortality risk in chronic kidney disease (CKD) patients using data from the NHANES survey from 2003 to 2018.
- It included 6,110 adult CKD patients and utilized various statistical models to analyze the impact of niacin on all-cause and cardiovascular disease (CVD) mortality.
- Results showed that higher dietary niacin intake (22 mg/day or more) is associated with a reduced risk of both all-cause mortality and CVD mortality in CKD patients.
Psilocybin Therapy for Clinicians With Symptoms of Depression From Frontline Care During the COVID-19 Pandemic: A Randomized Clinical Trial.
JAMA Netw Open
December 2024
Fred Hutchinson Cancer Center, Seattle, Washington.
Importance: The psychological morbidity experienced by physicians, advanced practice practitioners (APPs), and nurses from working during the COVID-19 pandemic includes burnout, depression, and posttraumatic stress disorder (PTSD).
Objective: To investigate whether psilocybin therapy could improve symptoms of depression, burnout, and PTSD in US clinicians who developed these symptoms from frontline clinical work during the pandemic.
Design, Setting, And Participants: This double-blind randomized clinical trial enrolled participants from February to December 2022.
Clinical and molecular characterization of familial chylomicronemia in Saudi patients: a retrospective study.
Front Endocrinol (Lausanne)
December 2024
Department of Pediatrics, King Faisal Specialist Hospital & Research Centre, Riyadh, Saudi Arabia.
Article Synopsis
- - Familial chylomicronemia syndrome (FCS) is a rare but severe form of hypertriglyceridemia, with over 100 cases identified at a specific center aimed at supporting clinicians and enhancing knowledge in disease management.
- - A study of 29 pediatric patients revealed common symptoms such as milky blood samples, family history of hypertriglyceridemia, and acute pancreatitis, with gemfibrozil and fenofibrate proving effective in lowering triglyceride levels.
- - The findings suggest anti-triglyceride medications, particularly fibrates, are safe and effective in managing FCS in kids, with gemfibrozil showing superior results compared to fenofibrate and both drugs causing minimal side effects
Multidomain Intervention Trial for Preventing Cognitive Decline among Older Adults with Type 2 Diabetes: J-MIND-Diabetes.
J Prev Alzheimers Dis
November 2024
Takashi Sakurai, 7-430 Morioka, Obu, Aichi 474-8511, Japan, E-mail: TEL: +81-562-46-2311.
Background: No multidomain intervention trials have been designed for the prevention of cognitive decline in older adults with type 2 diabetes.
Objectives: To investigate the efficacy of a multidomain intervention in preventing cognitive decline in older adults with type 2 diabetes and cognitive impairment.
Design: Eighteen-month, multi-centered, randomized controlled trial.
Systematic Review and Meta-Analysis on the Association Between Daily Niacin Intake and Glaucoma.
Nutrients
October 2024
Department of Pharmaceutical Marketing and Management, Faculty of Pharmacy, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania.
Article Synopsis
- Glaucoma is a progressive eye condition linked to mitochondrial dysfunction that causes damage to retinal ganglion cells, and this review aims to explore the effect of daily niacin intake on this disease.
- Five relevant studies were analyzed, revealing that individuals with higher niacin consumption were less likely to have glaucoma compared to those with lower intake, suggesting a possible protective effect of niacin.
- However, due to variations in niacin intake, glaucoma definitions, and other influencing factors, further large-scale, controlled trials are necessary to definitively establish the benefits of niacin for glaucoma patients.
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