Cystoid changes within astrocytic hamartomas of the retina in tuberous sclerosis.

Retin Cases Brief Rep

From the *Eye Clinic, Policlinico S. Orsola-Malpighi, Bologna, Italy; and †Ocular Oncology Service, Wills Eye Institute, Philadelphia, Pennsylvania.

Published: November 2014

Purpose: The purpose of this study was to report two unusual cases of cavitations within astrocytic hamartoma, a feature that causes the tumor to appear cystic. To our knowledge, this is the first report on cavitary astrocytic hamartoma.

Methods: In this observational case report, we identify two cases of cavitary astrocytic hamartoma imaged recently with spectral domain-optical coherence tomography.

Results: In both of our patients, the cavitary portion was visible clinically as an empty cavity surrounded by translucent tissue. Optical coherence tomography examination of both cases confirmed the presence of a cavity surrounded by tumor tissue.

Conclusion: In these two patients, optical coherence tomography showed a new feature of cavitation within retinal astrocytic hamartoma.

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http://dx.doi.org/10.1097/ICB.0b013e3181c59959DOI Listing

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Article Synopsis
  • The case reports on a patient with tuberous sclerosis complex (TSC) who developed branch retinal vein occlusion (BRVO) leading to retinal neovascularization (NV) and vitreous hemorrhage due to an astrocytic hamartoma (AH) located at the optic nerve head.
  • The study utilized electronic health records and advanced imaging techniques like fundus photography, fluorescein angiography, and optical coherence tomography (OCT) to analyze the patient's condition and identify the contributing factors.
  • The findings suggest that BRVO and its complications can pose serious risks to vision in patients with AH related to TSC, highlighting the usefulness of OCT in detecting and monitoring these retinal issues.
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