Indocyanine green angiography features of central areolar choroidal dystrophy.

Purpose: Central areolar choroidal dystrophy is an inherited autosomal dominant macular disease characterized by a central atrophy of the retinal pigment epithelium and choriocapillaris. Our purpose was to describe fluorescein angiography and confocal indocyanine green angiography features of central areolar choroidal dystrophy.

Methods: We performed a complete ophthalmologic examination including best corrected visual acuity, fundus examination, color fundus photographs, red free frames, fluorescein angiography, infrared, confocal indocyanine green, and electroretinography in a cohort of patients with a family history of central areolar choroidal dystrophy.

Results: Eleven patients (22 eyes) affected were prospectively included. Indocyanine green differentiated two distinct phenotypes. In 9/11 patients, atrophy area was hyperfluorescent or normofluorescent. In the two other patients, the lesion was hypofluorescent from early to late phases and pinpoints were observed on the late phases.

Conclusion: In our small series, indocyanine green angiography distinguished two phenotypes of central areolar choroidal dystrophy, correlated with fluorescein angiography features.