The morphological examination of 228 small-cell carcinomas and carcinoids of the lung, and evaluation of carcinoid tumor cataplasia versus posttreatment survival identified well-, moderately and poorly differentiated carcinoids. Well- and moderately differentiated tumors have a favorable clinical course and prognosis, though they tend to metastasize. Poorly differentiated carcinoids are characterized by an unfavorable course which is virtually similar to that of small-cell cancer. Prognosis of both malignancies was found to depend on primary tumor size and degree of regional lymph node involvement. Treatment should be determined by histologic type and degree of tumor extension. Well- and moderately differentiated carcinoids and the locoregional form of small-cell cancer make the case for surgery (which should be a component of combination treatment in the latter case). Complex and combination therapy should be used for poorly differentiated carcinoid and extended small-cell cancer.
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