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The Combination of Intravenous Immunoglobulin, Dexamethasone, and a High Dose of Mononuclear Cells Transfusion: An Effective Strategy for Decreasing Donor-Specific Antibodies During Haploidentical Hematopoietic Stem Cell Transplantation.
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Department of Hematology, 920th Hospital of Joint Logistics Support Force, Kunming, China.
Donor-specific antibodies (DSAs) are essential causes of graft rejection in haploidentical hematopoietic stem cell transplantation (haplo-HSCT). DSAs are unavoidable for some patients who have no alternative donor. Effective interventions to reduce DSAs are still needed, and the cost of the current therapies is relatively high.
View Article and Find Full Text PDFAttitude, Practice and Perceived Barrier for Tobacco Cessation Counseling and Nicotine Replacement Therapy among Private Dental Practitioners of North India: A Web based Survey.
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Department of Dentistry, Adesh Institute of Dental Sciences And Research, Bathinda, India.
Objective: To assess the attitude and practices towards the Tobacco Cessation Counselling and Nicotine Replacement Therapy and identify the possible barriers towards the implementation of these practices amongst Private dental practitioners of North, India. Methodology: A cross sectional web based survey using 33 item pre-tested self administered questionnaire was conducted. A total of 250 valid responses were received and were available for analysis.
View Article and Find Full Text PDFEmerging Immunotherapies for Disease Modification of Type 1 Diabetes.
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Division of Endocrinology, Department of Pediatrics, College of Medicine, University of Florida, 1699 SW 16th Ave, Building A, Gainesville, FL, 32608, USA.
Type 1 diabetes mellitus (T1DM) is characterized by the progressive, autoimmune-mediated destruction of β cells. As such, restoring immunoregulation early in the disease course is sought to retain endogenous insulin production. Nevertheless, in the more than 100 years since the discovery of insulin, treatment of T1DM has focused primarily on hormone replacement and glucose monitoring.
View Article and Find Full Text PDFPlatelet membrane-modified exosomes targeting plaques to activate autophagy in vascular smooth muscle cells for atherosclerotic therapy.
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Center for Coronary Heart Disease, Department of Cardiology, National Center for Cardiovascular Diseases of China, State Key Laboratory of Cardiovascular Disease, Fu Wai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, 167 Beilishi Rd, Beijing, 100037, China.
Atherosclerosis is one of the leading causes of ischemic cardiovascular disease worldwide. Recent studies indicated that vascular smooth muscle cells (VSMCs) play an indispensable role in the progression of atherosclerosis. Exosomes derived from mesenchymal stem cells (MSCs) have demonstrated promising clinical applications in the treatment of atherosclerosis.
View Article and Find Full Text PDFEffects of variable mating opportunity, delay, and male mating experience on the lifespan, female reproductive traits, and offspring traits of Phytoseiulus persimilis (Acari: Phytoseiidae).
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Manaaki Whenua - Landcare Research, 231 Morrin Road, Auckland, 1072, New Zealand.
The balance between mating benefits and costs shapes reproductive strategies and life history traits across animal species. For biological control programs, understanding how mating rates influence life history traits is essential for optimising population management and enhancing predator efficacy. This study investigates the impact of mating opportunity availability, delayed mating, and male mating history (copulation frequency) on the lifespan (both sexes), female reproductive traits (duration of oviposition and of pre- and post-oviposition periods, and lifetime oviposition), and offspring quality (egg size and offspring survival) of the predatory mite Phytoseiulus persimilis Athias-Henriot (Acari: Phytoseiidae), an important biological control agent against spider mites.
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