Household contacts are important sources of Bordetella pertussis in infants. A total of 353 household contacts of 97 index cases were evaluated for pertussis by culture and polymerase chain reaction. Twenty eight contacts were positive (8.0%). The presence of symptoms did not influence the rate of diagnosed bacteriologic pertussis in communicants. We conclude that contacts with an index case can be positive for B. pertussis independently of the presence of symptoms.
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http://dx.doi.org/10.1097/INF.0000000000000424 | DOI Listing |
Sci Rep
January 2025
Department of Global Health, University of Washington, Seattle, WA, USA.
Exposure to pulmonary tuberculosis (PTB) culminates in heterogeneous outcomes, including variation in Mtb antigen-specific interferon-gamma (IFN-γ) T-cell responses. IFN-γ-independent cytokines, including tumor necrosis factor (TNF) and interleukin (IL-2), offer potential diagnostic improvements and insights into pathogenesis. We hypothesized that ESAT6/CFP10 TNF and IL-2 responses improve Mtb infection detection among exposed household contacts (HHCs) and are associated with index case Mtb aerosolization (i.
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January 2025
Department of Ophthalmology, School of Medicine, Walailak University, Nakhon Si Thammarat, 80160, Thailand.
This is a prospective non-comparative experimental study aimed to investigate the presence of microsporidia in household pipe water of microsporidial keratitis (MK) patients and to describe the patients' characteristics and behavioral risk factors. This study was conducted at Walailak University Hospital, Thailand, from July 2022 to February 2024. Patients diagnosed with MK were surveyed using a questionnaire to assess personal behaviors and source of household water.
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January 2025
Department of Internal Medicine and Radboud Community for Infectious Diseases (RCI), Radboud University Medical Center, Nijmegen, the Netherlands.
Some individuals, even when heavily exposed to an infectious tuberculosis patient, do not develop a specific T-cell response as measured by interferon-gamma release assay (IGRA). This could be explained by an IFN-γ-independent adaptive immune response, or an effective innate host response clearing Mycobacterium tuberculosis (Mtb) without adaptive immunity. In heavily exposed Indonesian tuberculosis household contacts (n = 1347), a persistently IGRA negative status was associated with presence of a BCG scar, and - especially among those with a BCG scar - with altered innate immune cells dynamics, higher heterologous (Escherichia coli-induced) proinflammatory cytokine production, and higher inflammatory proteins in the IGRA mitogen tube.
View Article and Find Full Text PDFMikrobiyol Bul
October 2024
Dokuz Eylül University Faculty of Medicine, Department of Medical Microbiology, İzmir, Türkiye.
Measles, rubella, mumps and chickenpox infections are among the childhood diseases that can be prevented by vaccination. Healthcare workers are at greater risk of diseases transmitted through contact with patients' respiratory secretions, infected blood and body fluids. Students studying in the field of health are at the risk of encountering infectious diseases as much as healthcare personnel during their internship and practice experience in healthcare institutions during their education.
View Article and Find Full Text PDFFront Immunol
January 2025
Programa Multicêntrico de Bioquímica e Biologia Molecular/PMBqBM - Universidade Federal de Juiz de Fora - UFJF, Governador Valadares, MG, Brazil.
Introduction: Leprosy, a chronic infectious disease, is closely linked to the host immune response. According to the WHO, leprosy patients (L) and household contacts (HHC) are classified into subgroups: paucibacillary (PB) and multibacillary (MB), witch reflect the degree of infection in patients and the level of exposure of their contacts. The main goal of this study was to: i) establish a comprehensive overview of soluble mediator signatures of PBMCs upon antigen-specific stimuli and ii) identify whether the chemokine (CH) and cytokine (CY) signatures were associated with distinct clinical manifestations in (L) and immune response profiles in (HHC).
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