The development of readily tunable and regioselective C-H functionalization reactions that operate solely through catalyst control remains a challenge in modern organic synthesis. Herein, we report that simple silver catalysts supported by common nitrogenated ligands can be used to tune a nitrene transfer reaction between two different types of C-H bonds. The results reported herein represent the first example of ligand-controlled and site-selective silver-promoted C-H amination.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4277762 | PMC |
| http://dx.doi.org/10.1021/ja5094309 | DOI Listing |
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