AI Article Synopsis
- Taxanes like docetaxel and paclitaxel are chemotherapy drugs that stabilize microtubules and are effective against various solid tumors.
- In some patients, these drugs can lead to localized skin hardening, known as cutaneous sclerosis.
- A case is highlighted involving a patient with pre-existing CREST syndrome who experienced docetaxel-induced skin changes, suggesting that caution is needed when prescribing taxanes to those with a history of systemic sclerosis due to potential immune reactions.
Article Abstract
The taxanes, docetaxel and paclitaxel, are microtubule stabilizing chemotherapeutic agents that have demonstrated antineoplastic effects in a variety of solid tumors. They have been linked to the development of localized cutaneous sclerosis in some patients. We present a case of docetaxel-induced cutaneous sclerosis of the lower extremities in a patient with pre-existing CREST syndrome. We propose that patients with a history of limited or diffuse systemic sclerosis should be given taxane chemotherapy with caution, as these patients may have an immunological predisposition for the development of drug-induced morphea.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4211477 | PMC |
| http://dx.doi.org/10.4081/dr.2010.e9 | DOI Listing |
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