Starting from a primary amine-tethered alkyne , a copper-catalyzed three-component tandem amination/cyanation/alkylation sequence gives α-CN pyrrolidine in good yield and regioselectivity. Also, a silver mediated tandem amination/oxidation of a secondary amine-tethered alkyne produces functionalized pyrrole in good yield. All reactions were conducted in one pot without any protection/deprotection steps.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4224302 | PMC |
| http://dx.doi.org/10.1002/ejoc.201402748 | DOI Listing |
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