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| http://dx.doi.org/10.1370/afm.1727 | DOI Listing |
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A conceptual data model for IMM: A methodological interpretation of targets and indicators in SDG11.
Sci Total Environ
December 2024
Politecnico di Milano, Department of Architecture, Built Environment and Construction Engineering (DABC), Italy.
We are rapidly approaching the midpoint of the period set by the UN Agenda 2030 for transforming our activities on the planet Earth. Yet, many of the global issues we have begun with stand still while some of them took a much more severe course. The Sustainable Development Goals (SDGs) are unambiguous.
View Article and Find Full Text PDFAxially chiral α-boryl-homoallenyl boronic esters as versatile toolbox for accessing centrally and axially chiral molecules.
Nat Commun
October 2024
Department of Chemistry, Pohang University of Science and Technology (POSTECH), Pohang, 37673, Republic of Korea.
Axially chiral allenes bearing organoboron groups are highly sought-after building blocks in organic synthesis due to their potential for generating a wide range of axially and centrally chiral molecules. However, the existing methods for preparing axially chiral allenes containing boron group are primarily limited to the synthesis of allenyl boronic esters, and strategies for accessing axially chiral homoallenyl boronic esters are still scarce. Here, we report the general method for synthesizing axially chiral α-boryl-homoallenyl boronic esters through a highly regio- and stereoselective copper-mediated S2'-addition of newly prepared (diborylalkyl)copper species to chiral propargyl electrophiles.
View Article and Find Full Text PDFRefined movement analysis in the staircase test reveals differential motor deficits in mouse models of stroke.
J Cereb Blood Flow Metab
September 2024
Department of Neurology with Experimental Neurology, Charité - Universitätsmedizin Berlin, Berlin, Germany.
Article Synopsis
- - Accurate assessment of post-stroke deficits is essential for research, and advances in machine learning help quantify rodent motor behavior, but identifying specific upper extremity deficits remains unclear.
- - The study utilized techniques like proximal middle cerebral artery occlusion (MCAO) and cortical photothrombosis (PT) in mice, using tests and advanced imaging to analyze how stroke affects motor skills, particularly focusing on the forepaw's movement.
- - Findings showed that while general stroke volume didn't predict motor issues, specific patterns like forepaw slips and reaching success related directly to the size of cortical lesions, highlighting the importance of in-depth behavioral assessments in understanding stroke effects in preclinical research.
Assembling the RNA therapeutics toolbox.
Med Rev (2021)
April 2024
Department of Medical Biophysics, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada.
From the approval of COVID-19 mRNA vaccines to the 2023 Nobel Prize awarded for nucleoside base modifications, RNA therapeutics have entered the spotlight and are transforming drug development. While the term "RNA therapeutics" has been used in various contexts, this review focuses on treatments that utilize RNA as a component or target RNA for therapeutic effects. We summarize the latest advances in RNA-targeting tools and RNA-based technologies, including but not limited to mRNA, antisense oligos, siRNAs, small molecules and RNA editors.
View Article and Find Full Text PDFProfiles of Cognitive Functioning at 6 Months After Traumatic Brain Injury Among Patients in Level I Trauma Centers: A TRACK-TBI Study.
JAMA Netw Open
December 2023
Department of Neurological Surgery, University of California, San Francisco.
Importance: Cognitive dysfunction is common after traumatic brain injury (TBI), with a well-established dose-response relationship between TBI severity and likelihood or magnitude of persistent cognitive impairment. However, patterns of cognitive dysfunction in the long-term (eg, 6-month) recovery period are less well known.
Objective: To characterize the prevalence of cognitive dysfunction within and across cognitive domains (processing speed, memory, and executive functioning) 6 months after injury in patients with TBI seen at level I trauma centers.
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