Direct asymmetric hydrogenation of α-keto acids by using the highly efficient chiral spiro iridium catalysts. | LitMetric

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Direct asymmetric hydrogenation of α-keto acids by using the highly efficient chiral spiro iridium catalysts. | LitMetric

Direct asymmetric hydrogenation of α-keto acids by using the highly efficient chiral spiro iridium catalysts.

Pu-Cha Yan Jian-Hua Xie Xiang-Dong Zhang Kang Chen Yuan-Qiang Li Qi-Lin Zhou Da-Qing Che

Chem Commun (Camb)

Zhejiang Jiuzhou Pharmaceutical Co., Ltd., 99 Waisha Road, Jiaojiang District, Taizhou City, Zhejiang Province 318000, P. R. China.

Published: December 2014

A new method for asymmetric hydrogenation of α-keto acids has been developed using an Ir/SpiroPAP catalyst.
This method is both efficient and highly selective, meaning it produces a specific product more effectively.
It has potential for large-scale production of chiral α-hydroxy acids, which are important in various chemical applications.

A new efficient and highly enantioselective direct asymmetric hydrogenation of α-keto acids employing the Ir/SpiroPAP catalyst under mild reaction conditions has been developed. This method might be feasible for the preparation of a series of chiral α-hydroxy acids on a large scale.

Download full-text PDF	Source
http://dx.doi.org/10.1039/c4cc07643e	DOI Listing

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