AI Article Synopsis
- This study aimed to use breath-hold fMRI to identify brain regions with impaired cerebrovascular reactivity (CVR) in a female patient who experienced mild traumatic brain injury (mTBI).
- The researchers conducted two fMRI scans: one 2 months after the concussion and another 1 year later, analyzing changes in BOLD signals during a breath-hold challenge.
- Results showed significant neurovascular deficits initially, but a follow-up scan indicated that CVR normalized over time, suggesting CVR could be a useful imaging biomarker for mTBI diagnosis and recovery monitoring.
Article Abstract
Primary Objective: To use breath-hold functional magnetic resonance imaging (fMRI) to localize the brain regions with impaired cerebrovascular reactivity (CVR) in a female patient diagnosed with mild traumatic brain injury (mTBI). The extent of impaired CVR was evaluated 2 months after concussion. Follow-up scan was performed 1 year post-mTBI using the same breath-hold fMRI technique.
Research Design: Case report.
Methods And Procedures: fMRI blood oxygenation dependent level (BOLD) signals were measured under breath-hold challenge in a female mTBI patient 2 months after concussion followed by a second fMRI with breath-hold challenge 1 year later. CVR was expressed as the percentage change of BOLD signals per unit time of breath-hold.
Main Outcomes: In comparison with CVR measurement of normal control subjects, statistical maps of CVR revealed substantial neurovascular deficits and hemispheric asymmetry within grey and white matter in the initial breath-hold fMRI scan. Follow-up breath-hold fMRI performed 1 year post-mTBI demonstrated normalization of CVR accompanied with symptomatic recovery.
Conclusions: CVR may serve as an imaging biomarker to detect subtle deficits in both grey and white matter for individual diagnosis of mTBI. The findings encourage further investigation of hypercapnic fMRI as a diagnostic tool for mTBI.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4440418 | PMC |
| http://dx.doi.org/10.3109/02699052.2014.974209 | DOI Listing |
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