A novel class of aminonucleoside phospholipids has been developed. These molecules could spontaneously assemble into supramolecular structures including multilamellar organization, hydrogels, superhelical strands, and vesicles. Their ability to bind to DNA by hydrogen bonding and π-π stacking interactions was investigated by many means.
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Supramolecular assemblies of novel aminonucleoside phospholipids and their bonding to nucleic acids.
Chem Commun (Camb)
January 2015
State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Xue Yuan Road 38, Beijing 100191, China.
A novel class of aminonucleoside phospholipids has been developed. These molecules could spontaneously assemble into supramolecular structures including multilamellar organization, hydrogels, superhelical strands, and vesicles. Their ability to bind to DNA by hydrogen bonding and π-π stacking interactions was investigated by many means.
View Article and Find Full Text PDFProtection of alpha(3) integrin-mediated podocyte shape by superoxide dismutase in the puromycin aminonucleoside nephrosis rat.
Am J Kidney Dis
June 2000
Department of Internal Medicine, Teikyo University School of Medicine, Kaga, Itabashi-ku, Tokyo, Japan.
Because reactive oxygen species (ROS) are involved in the development of puromycin aminonucleoside nephrosis (PAN), we examined whether superoxide dismutase (SOD) could ameliorate this condition. Phosphatidyl choline-bound SOD (PC-SOD) has higher affinity for the cell membrane than recombinant human SOD (rhSOD). In this study, PC-SOD had a longer half-life in the circulation and also higher affinity to renal fractions (glomerulus, brush border, and tubulus) than rhSOD.
View Article and Find Full Text PDFEffect of sairei-to on prostaglandin E2-induced phosphatidylinositol breakdown in aminonucleoside nephrotic rat.
Nephron
May 1997
Department of Pediatrics, Fukushima Medical College, Japan.
We describe the effects of Sairei-to, a Chinese herbal medicine, on aminonucleoside-induced nephrotic rats (ANNR), and analyze the urinary excretion of protein and phosphatidylinositol (PI) turnover via prostaglandin E2 (PGE2) receptors in isolated glomeruli. Sairei-to suppressed urinary excretion of protein and PGE2 in ANNR, and inhibited acceleration of PI turnover in isolated nephrotic glomeruli. The affected responsiveness of the PI turnover system to PGE2 in a nephrotic state was presumed to be normalized by Sairei-to.
View Article and Find Full Text PDF[Influence of corticosteroid on phosphatidylinositol turnover in aminonucleoside-induced nephrotic rat kidney].
Nihon Jinzo Gakkai Shi
September 1996
Department of Pediatrics, Fukushima Medical College, Japan.
To clarify the changes in the intracellular signal transduction system in the kidneys of aminonucleoside (AN)-induced nephrotic rats and the effect of steroid on these changes, we investigated the urinary protein excretion and PGE2 excretion with and without steroid administration as well as the metabolic turnover system of phosphatidylinositol (PI), which is one of the intracellular signal transduction systems mediated by the PGE2 receptor of the glomerulus isolated from the kidney. The following results were obtained: (10 The action of steroid in inhibiting proteinuria was not correlated with its action in inhibiting PGE2 production. (2) Enhanced PI turnover of the glomerulus isolated from the kidney was observed in the state of nephrosis.
View Article and Find Full Text PDFChanges in glycerophospholipid profile in experimental nephrotic syndrome.
Metabolism
July 1996
Department of Biochemistry, The Cecil H. & Ida Green Center for Reproductive Biology Sciences, The University of Texas Southwestern Medical Center at Dallas, TX 75235-9051, USA.
We investigated changes in the glycerophospholipids in kidney tissue and its various intracellular fractions in rats with nephrotic syndrome induced by puromycin aminonucleoside. The ethanolamine plasmalogen, 1-O-alk-1'-enyl-2-acyl-GPE (EP), was increased in kidney tissue obtained from the puromycin-treated animals. A similar increase was found in the mitochondria and endoplasmic reticulum (microsomes) of this tissue.
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