Purpose: To report an original case of retinal pigment epithelial (RPE) tears in acute Vogt-Koyanagi-Haradadisease.

Methods: Observational case report of a patient who presented with RPE tears in acute Vogt-Koyanagi-Harada disease, who underwent clinical examination, fluorescein and infracyanine green angiographies, and optical coherence tomography evaluation.

Results: A 42-year-old woman presented with bilateral serous retinal detachment related to Vogt-Koyanagi-Harada disease. Eight days after high-dose systemic corticosteroids, she developed bilateral RPE tears. At the 15-month follow-up, visual acuity was 20/20 in both eyes.

Conclusion: The RPE tears are rarely observed in acute Vogt-Koyanagi-Harada disease. The RPE tears were likely caused by acute inflammation of the choroidal stroma.

Download full-text PDF

Source
http://dx.doi.org/10.1097/ICB.0b013e3182964f68DOI Listing

Publication Analysis

Top Keywords

rpe tears
20
vogt-koyanagi-harada disease
16
tears acute
12
acute vogt-koyanagi-harada
12
retinal pigment
8
tears
6
acute
5
rpe
5
bilateral retinal
4
pigment epithelium
4

Similar Publications

Candidate Tear-Based Uveitis Biomarkers in Children with JIA Based on Arthritis Activity and Topical Corticosteroid Use.

Ocul Immunol Inflamm

November 2024

Division of Rheumatology, Cincinnati Children's Hospital Medical Center and Department of Pediatrics, University of Cincinnati, Cincinnati, Ohio, USA.

Background: Uveitis is an inflammatory ocular disease secondary to disruption of the retinal pigmented epithelium (RPE) and blood retinal barrier (BRB). Known clinical factors do not accurately predict uveitis risk in Juvenile Idiopathic Arthritis (JIA). Tear fluid is easily obtained for biomarker study.

View Article and Find Full Text PDF

RESPONSE TO LETTER TO THE EDITOR: RPE Tears: A Deeper Dive.

Retina

October 2024

Retinal Disorders and Ophthalmic Genetics Division, Stein Eye Institute, University of California of Los Angeles, David Geffen School of Medicine at UCLA, Los Angeles, California, United States.

View Article and Find Full Text PDF

The toxic effects of polystyrene microplastic/nanoplastic particles on retinal pigment epithelial cells and retinal tissue.

Environ Sci Pollut Res Int

September 2024

Department of Ophthalmology, Guro Hospital, Korea University College of Medicine, 80, Guro-Dong, Guro-Gu, Seoul, 152-703, South Korea.

Article Synopsis
  • The increasing use of contact lenses and other eye-related products has led to greater exposure to microplastics, raising concerns about their impact on eye health, particularly the retina.
  • This study tested the effects of microplastics (MPs) and nanoplastics (NPs) on human retinal pigment epithelial cells and found that while MPs didn't significantly affect cell viability, NPs caused notable damage and increased oxidative stress.
  • In animal tests, NPs increased inflammatory markers and the presence of inflammatory cells in the retina, highlighting that NPs are more harmful than MPs, given their role in inducing oxidative stress and mitochondrial changes in retinal cells.
View Article and Find Full Text PDF

We report the familial occurrence of a severe phenotype of central serous chorioretinopathy (CSC). A 62-year-old man was referred to our institute to treat a macular lesion in his right eye. Best-corrected visual acuity (BCVA) in his right eye was 0.

View Article and Find Full Text PDF

The factors associated with retinal pigment epithelium tear development in the early phase after treatment initiation for age-related macular degeneration.

Graefes Arch Clin Exp Ophthalmol

October 2024

Department of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-Ku, Fukuoka, 812-8582, Japan.

Purpose: This study aimed to evaluate the factors associated with retinal pigment epithelium (RPE) tear development in the early phase after anti-vascular endothelial growth factor (VEGF) drug initiation in eyes with neovascular age-related macular degeneration (nAMD) and retinal pigment epithelial detachment (PED).

Methods: Treatment-naive eyes with nAMD and PED for which anti-VEGF drug injections had been initiated and followed up for at least 3 months after the 1st anti-VEGF drug injection, were retrospectively investigated. Baseline characteristics of the PEDs, including type, height, and area, were evaluated using fundus photographs, fluorescein angiography, and optical coherence tomography images.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!