The dependence of the end-plate potentials inhibition upon the prevention of the muscle twitches either by tubocurarine, or alpha-neurotoxin, or cutting of the fibers was studied during nerve tetanization in the frog isolated cutaneous pectoral muscles. The decrease in end-plate potentials in the course of tetanization was the strongest under the effect of tubocurarine. The latter seems to inhibit the quantum release of acetylcholine during the nerve tetanization.
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