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Formal total syntheses of classic natural product target molecules via palladium-catalyzed enantioselective alkylation. | LitMetric

Formal total syntheses of classic natural product target molecules via palladium-catalyzed enantioselective alkylation.

Beilstein J Org Chem

Warren and Katharine Schlinger Laboratory of Chemistry and Chemical Engineering, Division of Chemistry and Chemical Engineering, California Institute of Technology, 1200 E. California Boulevard, Pasadena, CA, USA.

Published: November 2014

AI Article Synopsis

Article Abstract

Pd-catalyzed enantioselective alkylation in conjunction with further synthetic elaboration enables the formal total syntheses of a number of "classic" natural product target molecules. This publication highlights recent methods for setting quaternary and tetrasubstituted tertiary carbon stereocenters to address the synthetic hurdles encountered over many decades across multiple compound classes spanning carbohydrate derivatives, terpenes, and alkaloids. These enantioselective methods will impact both academic and industrial settings, where the synthesis of stereogenic quaternary carbons is a continuing challenge.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4222294PMC
http://dx.doi.org/10.3762/bjoc.10.261DOI Listing

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