Background: Although fragmented QRS complex (frag-QRS) reflecting intra-ventricular conduction delay has been shown to be a prognostic marker for cardiac events, few data exist regarding the impact of frag-QRS on cardiac events in hypertrophic cardiomyopathy (HCM).

Methods And Results: Ninety-four HCM patients (56 male; mean age, 58 ± 17 years) were retrospectively investigated. Frag-QRS was defined as the presence of various RsR' patterns in at least 2 contiguous ECG leads. Major arrhythmic events (MAE) were defined as sudden cardiac death, and combined sustained ventricular tachycardia/ventricular fibrillation. New-onset atrial fibrillation (AF) was diagnosed based on ECG during provisional or routine medical examination. Heart failure (HF) with hospitalization was defined as hospital admission due to subjective or objective symptoms. Frag-QRS was detected in 31 patients (33%).TNNI3 was the most frequent disease-causing gene. Median follow-up was 4.6 years. The 4-year cumulative survival rates of cardiac death, MAE, new-onset AF and HF with hospitalization were 97.6%, 94.6%, 87.5% and 89.3%, respectively. On multivariate analysis, frag-QRS was significantly associated with HF with hospitalization (adjusted hazard ratios [95% confidence intervals]: 5.4 [1.2-36], P=0.03). Moreover, HF-free survival was significantly lower in the frag-QRS (+) group compared to the frag-QRS (-) group (79.0% vs. 95.1%, P=0.03).

Conclusions: Frag-QRS is associated with HF with hospitalization in HCM patients who had a unique distribution of gene mutations.

Download full-text PDF

Source
http://dx.doi.org/10.1253/circj.CJ-14-0822DOI Listing

Publication Analysis

Top Keywords

fragmented qrs
8
heart failure
8
hypertrophic cardiomyopathy
8
frag-qrs
8
cardiac events
8
hcm patients
8
cardiac death
8
frag-qrs associated
8
associated hospitalization
8
frag-qrs group
8

Similar Publications

Objective: Menopause significantly impacts cardiovascular health, yet the relationship between myocardial abnormalities and noncardiac symptoms in postmenopausal women remains underexplored. This study aims to investigate the association between fragmented QRS waves (fQRS) positivity on electrocardiograms (ECG) and somatic symptoms in postmenopausal women.

Methods: We included 623 postmenopausal women attending a menopause clinic for routine annual gynecological examinations.

View Article and Find Full Text PDF

Female sex is one of the Long COVID (LC) risk factors; however, the LC predictors in females have not been established. This study was conducted to assess the influence of LC on the cardiovascular system and to assess the age-independent predictors of LC in females. : Patient information and the course of the disease with symptoms were collected in women at least 12 weeks after COVID-19 recovery.

View Article and Find Full Text PDF

Introduction: Early detection of cardiac sarcoidosis (CS) is crucial due to its association with severe complications such as ventricular arrhythmias, heart failure, and sudden cardiac death. Advanced imaging techniques like cardiac magnetic resonance imaging (CMR) and 18F-Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography (FDG-PET/CT) are effective in detecting CS but not easily accessible. The optimal method for selecting patients for advanced screening remains uncertain.

View Article and Find Full Text PDF
Article Synopsis
  • Acute pulmonary embolism can lead to rapid collapse and is often fatal, with recent studies showing ECG characteristics can help predict patient outcomes.
  • This retrospective study analyzed the ECG data of 106 hospitalized pulmonary embolism patients from 2016 to 2020 to determine the frequency of fragmented QRS and its prognostic implications.
  • Results revealed that fragmented QRS was found in 26.2% of patients, which correlated significantly with higher rates of cardiogenic shock, in-hospital mortality, and the use of advanced treatments like thrombolysis and embolectomy.
View Article and Find Full Text PDF

In determining the culprit vessel responsible for inferior ST-segment elevation myocardial infarction (STEMI) as either the right coronary artery (RCA) or left circumflex (LCX), the electrocardiographic value has been validated. However, its ability to predict whether inferior STEMI is complicated by left anterior descending artery (LAD) chronic total occlusion remains uncertain. Based on the involvement of arteries other than the culprit vessels, 189 patients with inferior STEMI from our chest pain center were categorized into four groups: LAD occlusion group (n = 20), LAD stenosis > 50% group (n = 116), normal LAD group (n = 27), and other vessel stenosis > 50% group (n = 26).

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!