Recent dense granular flow experiments have shown that shear deformation in one region of a granular medium fluidizes its entirety, including regions far from the sheared zone, effectively erasing the yield condition everywhere. This enables slow creep deformation to occur when an external force is applied to a probe in the nominally static regions of the material. The apparent change in rheology induced by far-away motion is termed the "secondary rheology," and a theoretical rationalization of this phenomenon is needed. Recently, a new nonlocal granular rheology was successfully used to predict steady granular flow fields, including grain-size-dependent shear-band widths in a wide variety of flow configurations. We show that the nonlocal fluidity model is also capable of capturing secondary rheology. Specifically, we explore creep of a circular intruder in a two-dimensional annular Couette cell and show that the model captures all salient features observed in experiments, including both the rate-independent nature of creep for sufficiently slow driving rates and the faster-than-linear increase in the creep speed with the force applied to the intruder.
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http://dx.doi.org/10.1103/PhysRevLett.113.178001 | DOI Listing |
Blood
January 2025
New York Blood Center, New York, New York, United States.
Babesiosis in sickle cell disease (SCD) is marked by severe anemia but the underlying red blood cell (RBC) rheological parameters remain largely undefined. Here, we describe altered RBC deformability from both primary (host RBC sickle hemoglobin mediated) and secondary changes (Babesia parasite infection mediated) to the RBC membrane using wild type AA, sickle trait AS and sickle SS RBCs. Our ektacytometry (LORRCA) analysis demonstrates that the changes in the host RBC bio-mechanical properties, pre- and post- Babesia infection, reside on a spectrum of severity, with wild type infected AA cells, despite showing a significant reduction of deformability under both shear and osmolarity gradients, exhibiting only a mild phenotype; compared to infected AS RBCs which show median changes in deformability and infected SS RBCs which exhibit the most dramatic impact of infection on cellular rheology, including an increase in Point of Sickling values.
View Article and Find Full Text PDFFood Res Int
February 2025
Hubei Key Laboratory for Processing and Transformation of Agricultural Products (Wuhan Polytechnic University), Wuhan 430023, Hubei, China; Department of Food Science and Engineering, Wuhan Polytechnic University, Wuhan, 430023, Hubei, China. Electronic address:
This study investigated the effect of wheat bran (WB) with different particle sizes (W1, 155.00 ± 2.08 μm; W2, 78.
View Article and Find Full Text PDFJ Chromatogr A
January 2025
Home and Personal Care, The Dow Chemical Company, Shanghai 201203, PR China.
Rheology modifiers (RMs) are polymeric molecules providing rheological control of formulations, which are important in product application, shelf-life, and aesthetic perception. Bio-derived polyethylene glycol (PEG)-based RMs thicken formulations through nonionic-associative thickening where at least two hydrophobic end groups from a RM molecule interact with other hydrophobic groups of other RM molecules or ingredients in the formulation to form an associative network. We report a comprehensive two-dimensional liquid chromatography (2D-LC) separation of partly bio-derived PEG-based RMs in size exclusion chromatography (SEC) × reversed-phase liquid chromatography (RPLC) mode for the separation of RM components based on both molecular weight distribution and end group hydrophobe distribution.
View Article and Find Full Text PDFBiomed Mater
January 2025
Department of Biomedical Engineering, University of Connecticut, Storrs, CT 06269, United States of America.
Articular cartilage and osteochondral defect repair and regeneration presents significant challenges to the field of tissue engineering (TE). TE and regenerative medicine strategies utilizing natural and synthetic-based engineered scaffolds have shown potential for repair, however, they face limitations in replicating the intricate native microenvironment and structure to achieve optimal regenerative capacity and functional recovery. Herein, we report the development of a cartilage extracellular matrix (ECM) as a printable biomaterial for tissue regeneration.
View Article and Find Full Text PDFNat Commun
January 2025
Center for Engineering in Medicine and Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA, 02114, USA.
Circulating Tumor Cells (CTCs) in blood encompass DNA, RNA, and protein biomarkers, but clinical utility is limited by their rarity. To enable tumor epitope-agnostic interrogation of large blood volumes, we developed a high-throughput microfluidic device, depleting hematopoietic cells through high-flow channels and force-amplifying magnetic lenses. Here, we apply this technology to analyze patient-derived leukapheresis products, interrogating a mean blood volume of 5.
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