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Clozapine for Parkinson's disease psychosis in a septuagenarian: a nightmare turned into bliss.
Neurol Sci
October 2024
Department of Neurology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, 221005, India.
Parkinson's disease psychosis, characterized by confusion, visual hallucinations, and delusions is a nightmare for the patients and caregivers. Classic neuroleptics aggravate the motor symptoms, hence the need for an effective atypical antipsychotic. Currently Pimavanserin is the only approved drug for Parkinson's disease psychosis (PDP), however it is not readily available.
View Article and Find Full Text PDFLevodopa-responsive dystonia, parkinsonism, and treatment-resistant schizoaffective disorder in Williams syndrome.
Neurol Sci
January 2025
Institute of Medical Science, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada.
Article Synopsis
- Williams syndrome (WS) is a rare genetic disorder linked to chromosome 7, characterized by developmental delays and various neuropsychiatric issues, including movement disorders and psychiatric conditions.
- The study presents two adult cases of WS with severe treatment-resistant schizoaffective disorder and associated movement issues, such as parkinsonism and dystonia, observed after clozapine treatment.
- The findings suggest that low-dose levodopa may effectively alleviate movement symptoms without worsening psychotic or mood symptoms, indicating new potential treatment avenues for individuals with WS.
Indole induces anxiety-like behaviour in mice mediated by brainstem locus coeruleus activation.
Neurobiol Dis
October 2024
Shenzhen Institute of Advanced Technology (SIAT), Chinese Academy of Sciences, Guangdong Provincial Key Laboratory of Brain Connectome and Behaviour, CAS Key Laboratory of Brain Connectome and Manipulation, Shenzhen-Hong Kong Institute of Brain Science-Shenzhen Fundamental Research Institutions, Shenzhen, China. Electronic address:
The gut microbiota produces metabolites that enrich the host metabolome and play a part in host physiology, including brain functions. Yet the biological mediators of this gut-brain signal transduction remain largely unknown. In this study, the possible role of the gut microbiota metabolite indole, originating from tryptophan, was investigated.
View Article and Find Full Text PDFAnalysis of antipsychotic drugs prescribing in incarcerated persons in a Serbian correctional facility.
Int J Prison Health (2024)
February 2024
Department of Pharmacology, Clinical Pharmacology and Toxicology, Faculty of Medicine, University of Belgrade, Belgrade, Serbia.
Purpose: Prison settings have limited resources, and it is of particular interest to analyze which antipsychotics are commonly prescribed in these conditions and to determine the prevalence of the adverse effects.
Design/methodology/approach: A cross-sectional, epidemiological survey was used to measure the prevalence of antipsychotic prescribing among adult prisoners in Sremska Mitrovica Prison in 2020.
Findings: The prevalence of antipsychotic use was 7.
Safe and Effective Use of Low-Dose Clozapine for Tardive Dyskinesia in a Patient with Schizophrenia and Comorbid Epilepsy: A Case Report.
Psychiatry Clin Psychopharmacol
June 2023
Department of Psychiatry, Muğla Sıtkı Koçman University Faculty of Medicine, Muğla, Turkey.
Atypical antipsychotic clozapine has a special therapeutic impact on tardive dyskinesia and treatment-resistant schizophrenia. Clozapine also has important adverse effects such as epileptic seizures. For this reason, most clinicians avoid using clozapine in patients with schizophrenia and epilepsy.
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