AI Article Synopsis

  • Researchers have created unique biocompatible polymer particles that can interact differently with human endothelial cells, thanks to their distinctive two-sided nature.
  • These particles are made using a technique called electro-hydrodynamic co-jetting, where two different polymer solutions are combined to form the anisotropic shape.
  • After forming these particles, the surface is selectively altered to enhance their functionality, making them useful for developing microstructured bio-hybrid materials.

Article Abstract

Biocompatible anisotropic polymer particles with bipolar affinity towards human endothelial cells are a novel type of building blocks for microstructured bio-hybrid materials. Functional polarity due to two biologically distinct hemispheres has been achieved by synthesis of anisotropic particles via electro-hydrodynamic co-jetting of two different polymer solutions and subsequent selective surface modification.

Download full-text PDF

Source
http://dx.doi.org/10.1002/adma.200901971DOI Listing

Publication Analysis

Top Keywords

bio-hybrid materials
8
human endothelial
8
endothelial cells
8
structurally controlled
4
controlled bio-hybrid
4
materials based
4
based unidirectional
4
unidirectional association
4
association anisotropic
4
anisotropic microparticles
4

Similar Publications

Arginine-Biofunctionalized Ternary Hydrogel Scaffolds of Carboxymethyl Cellulose-Chitosan-Polyvinyl Alcohol to Deliver Cell Therapy for Wound Healing.

Gels

October 2024

Center of Nanoscience, Nanotechnology, and Innovation-CeNano2I, Department of Metallurgical and Materials Engineering, Federal University of Minas Gerais, UFMG, Av. Presidente Antônio Carlos, 6627-Escola de Engenharia, Bloco 2-Sala 2233, Belo Horizonte 31270-901, MG, Brazil.

Wound healing is important for skin after deep injuries or burns, which can lead to hospitalization, long-term morbidity, and mortality. In this field, tissue-engineered skin substitutes have therapy potential to assist in the treatment of acute and chronic skin wounds, where many requirements are still unmet. Hence, in this study, a novel type of biocompatible ternary polymer hybrid hydrogel scaffold was designed and produced through an entirely eco-friendly aqueous process composed of carboxymethyl cellulose, chitosan, and polyvinyl alcohol and chemically cross-linked by citric acid, forming three-dimensional (3D) matrices, which were biofunctionalized with L-arginine (L-Arg) to enhance cellular adhesion.

View Article and Find Full Text PDF

The assembly of pH-responsive DNA-based, phase-separated microdroplets (MDs) coacervates, consisting of frameworks composed of Y-shaped nucleic acid modules crosslinked by pH-responsive strands, is introduced. The phase-separated MDs reveal dynamic pH-stimulated switchable or oscillatory transient depletion and reformation. In one system, a photoisomerizable merocyanine/spiropyran photoacid is used for the light-induced pH switchable modulation of the reaction medium between the values pH=6.

View Article and Find Full Text PDF

Sustainable biofabrication: from bioprinting to AI-driven predictive methods.

Trends Biotechnol

July 2024

Soft Robotics Laboratory, ETH Zurich, Tannenstrasse 3, Zurich, 8092, Switzerland. Electronic address:

Biofabrication is potentially an inherently sustainable manufacturing process of bio-hybrid systems based on biomaterials embedded with cell communities. These bio-hybrids promise to augment the sustainability of various human activities, ranging from tissue engineering and robotics to civil engineering and ecology. However, as routine biofabrication practices are laborious and energetically disadvantageous, our society must refine production and validation processes in biomanufacturing.

View Article and Find Full Text PDF

Bio-Hybrid Magnetic Robots: From Bioengineering to Targeted Therapy.

Bioengineering (Basel)

March 2024

Institute of Artificial Intelligence, Xiamen University, Xiamen 361005, China.

Magnetic robots possess an innate ability to navigate through hard-to-reach cavities in the human body, making them promising tools for diagnosing and treating diseases minimally invasively. Despite significant advances, the development of robots with desirable locomotion and full biocompatibility under harsh physiological conditions remains challenging, which put forward new requirements for magnetic robots' design and material synthesis. Compared to robots that are synthesized with inorganic materials, natural organisms like cells, bacteria or other microalgae exhibit ideal properties for in vivo applications, such as biocompatibility, deformability, auto-fluorescence, and self-propulsion, as well as easy for functional therapeutics engineering.

View Article and Find Full Text PDF

Visualized in-sensor computing.

Nat Commun

April 2024

Institute of Optoelectronic Thin Film Devices and Technology, Key Laboratory of Optoelectronic Thin Film Devices and Technology of Tianjin, College of Electronic Information and Optical Engineering, National Institute for Advanced Materials, Nankai University, Tianjin, 300350, China.

In artificial nervous systems, conductivity changes indicate synaptic weight updates, but they provide limited information compared to living organisms. We present the pioneering design and production of an electrochromic neuromorphic transistor employing color updates to represent synaptic weight for in-sensor computing. Here, we engineer a specialized mechanism for adaptively regulating ion doping through an ion-exchange membrane, enabling precise control over color-coded synaptic weight, an unprecedented achievement.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!