AI Article Synopsis
- Observational studies indicate vitamin D may help prevent blood clotting.
- A study involving 73 healthy participants measured the effects of vitamin D3 supplementation on thrombin generation.
- Results showed significant changes in thrombin generation parameters after treatment, suggesting vitamin D may increase blood clotting in those with vitamin D deficiency, but more research is needed to confirm these findings.
Article Abstract
Observational and in vitro studies suggest that vitamin D may have antithrombotic activity. This study aimed to examine the relationship between vitamin D supplementation and thrombin generation. Serum 25-hydroxyvitamin D (25(OH)D) and thrombin generation parameters were measured in 73 healthy volunteers. Participants with serum 25(OH)D <50 nmol/L (n = 53) were treated with vitamin D3and tested for 25(OH)D and thrombin generation at the end of treatment. Lag time and time to peak decreased after treatment by a mean of -0.49 ± 0.51 minute (P< .001) and -0.76 ± 0.70 minute (P< .001), respectively, whereas endogenous thrombin potential and peak height increased after treatment by a mean of 170.1 ± 339.8 nmol/L minute (P= .001) and 34.2 ± 47.8 nmol/L (P< .001), respectively. Treatment with vitamin D supplementation seems to have prothrombotic effect in patients with vitamin D insufficiency. These findings should be interpreted with caution and need to be replicated in future studies.
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| http://dx.doi.org/10.1177/1076029614556745 | DOI Listing |
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