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Mpox: emergence following smallpox eradication, ongoing outbreaks and strategies for prevention.
Curr Opin Infect Dis
January 2025
Division of Pediatric Infectious Diseases, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.
Purpose Of Review: This review focuses on the temporal relationship between the discontinuation of the global smallpox eradication effort with the rise of mpox in Africa and worldwide. It also discusses the global 2022 clade II mpox epidemic and the current 2024 clade I mpox outbreak. Newer findings on viral evolution and pathogenesis, plus current and future strategies for disease prevention, are reviewed.
View Article and Find Full Text PDFDesign, Synthesis and Anti-Inflammatory Evaluation of 3-Substituted 5-Amidobenzoate Derivatives as Novel P2Y Receptor Antagonists via Structure-Guided Molecular Hybridization.
J Med Chem
January 2025
College of Chemistry, Zhengzhou University, Zhengzhou 450001, China.
The P2YR is activated by UDP and UDP glucose and is involved in many human inflammatory diseases. Based on the molecular docking analysis of currently reported P2YR antagonists and the crystallographic overlap study between PPTN and compound , a series of 3-substituted 5-amidobenzoate derivatives were designed, synthesized, and identified as promising P2YR antagonists. The optimal compound (methyl 3-(1-benzo[]imidazol-2-yl)-5-(2-(-tolyl) acetamido)benzoate, IC = 0.
View Article and Find Full Text PDFPreventing and Treating Delayed Gastric Emptying (DGE) after Pancreatic Surgery: A Systematic Review and Meta-analysis of Randomized Controlled Trials.
Ann Surg
January 2025
Amsterdam UMC, location University of Amsterdam, Department of Surgery, Amsterdam, the Netherlands.
Objective: To identify strategies to prevent and treat delayed gastric emptying (DGE) after pancreatic surgery.
Background: Among all complications of pancreatic surgery, DGE has the largest impact on prolonged hospital stay. Several randomized controlled trials (RCTs) have addressed DGE after pancreatic surgery, either as primary or as secondary outcome.
Health literacy status and associated factors among residents in Anhui Province, China: a cross-sectional study.
Front Public Health
January 2025
Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei, China.
Background: Health literacy (HL) is a critical determinant of health outcomes. Improving HL stands as one of the most essential, cost-effective, and efficacious strategies for enhancing the overall health of the population. This study aims to analyze the status of HL among urban and rural residents in Anhui Province, explore the associated factors, and provide a scientific basis for the formulation of targeted health education and promotion strategies.
View Article and Find Full Text PDFCoping strategies and correlations with depressive symptoms among female nurses working in Japanese general hospitals.
Front Public Health
January 2025
Department of Psychiatry, Nihon University School of Medicine, Tokyo, Japan.
Introduction: Preventing depression among nurses is a critical issue from the perspective of occupational welfare, but associations between depressive symptoms in nurses and stress-coping strategies remain unclear.
Methods: In the present study, an epidemiological study was conducted based on a cross-sectional questionnaire survey. Data obtained from 2,534 female nurses working at three general hospitals in Tokyo, Japan, were analyzed.
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