Literature data for picosecond mean square displacements show that the anharmonicity explains only about half of the fragility (with different fractions for different glass formers). The other half must be ascribed to the Adam-Gibbs mechanism of a growing cooperatively rearranging region. One can measure both influences separately by a simultaneous measurement of liquid and crystal in the coexistence region.
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http://dx.doi.org/10.1103/PhysRevE.90.042312 | DOI Listing |
J Immunother Cancer
January 2025
Key laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Gastrointestinal Surgery III, Peking University Cancer Hospital & Institute, Beijing, China
Background: B-Raf proto-oncogene, serine/threonine kinase (BRAF)-mutant microsatellite stable (MSS) colorectal cancer (CRC) constitutes a distinct CRC subgroup, traditionally perceived as minimally responsive to standard therapies. Recent clinical attempts, such as BRAF inhibitors (BRAFi) monotherapy and combining BRAFi with other inhibitors, have yielded unsatisfactory efficacy. This study aims to identify a novel therapeutic strategy for this challenging subgroup.
View Article and Find Full Text PDFFoods
December 2024
Division of Data, Statistics and Risk Assessment, Austrian Agency for Health and Food Safety AGES, 1220 Vienna, Austria.
Plant-derived foods are potential vehicles for microbial antibiotic resistance genes (ARGs), which can be transferred to the human microbiome if consumed raw or minimally processed. The aim of this study was to determine the prevalence and the amount of clinically relevant ARGs and mobile genetic elements (MGEs) in differently processed smoothies (freshly prepared, cold-pressed, pasteurized and high-pressure processed) and fresh produce samples (organically and conventionally cultivated) to assess potential health hazards associated with their consumption. The MGE and the class 1 integron-integrase gene were detected by probe-based qPCR in concentrations up to 10 copies/mL in all smoothies, lettuce, carrots and a single tomato sample.
View Article and Find Full Text PDFBiomolecules
December 2024
CAS Key Laboratory of Colloid, Interface and Chemical Thermodynamics, CAS Research/Education Center for Excellence in Molecular Sciences, Beijing National Laboratory for Molecular Sciences (BNLMS), Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China.
Due to their high biocompatibility, biodegradability, and facile surface functionalization, phospholipid vesicles as carriers have garnered significant attention in the realm of disease diagnosis and treatment. On the one hand, phospholipid vesicles can function as probes for the detection of various diseases by encapsulating nanoparticles, thereby enabling the precise localization of pathological changes and the monitoring of disease progression. On the other hand, phospholipid vesicles possess the capability to selectively target and deliver therapeutic agents, including drug molecules, genes and immune modulators, to affected sites, thereby enhancing the sustained release of these agents and improving therapeutic efficacy.
View Article and Find Full Text PDFACS Omega
December 2024
Department of Gastroenterology, Xiamen University Affiliated Chenggong Hospital, Xiamen City, Fujian Province 361003, China.
MicroRNAs (miRNAs), which play critical roles in regulating gene expression and cell functions, are recognized as potential biomarkers for various human diseases, including gastric ulcers. The reliable, specific, and sensitive detection of miRNA is highly recommended for the clinical diagnosis and therapy of different diseases. Herein, we depict a label-free and low-background fluorescent assay for the highly sensitive detection of miRNAs by coupling target miRNA-triggered cyclization of a padlock, circular padlock-mediated catalytic hairpin assembly (CHA), and primer exchange reaction (PER)-assisted signal generation.
View Article and Find Full Text PDFThromb Haemost
December 2024
Department of Brain Sciences, Imperial College London, London, United Kingdom.
Adequate secondary prevention in survivors of intracerebral hemorrhage (ICH) who also have atrial fibrillation (AF) is a long-standing clinical dilemma because these patients are at increased risk of recurrent ICH as well as of ischemic stroke. The efficacy and safety of oral anticoagulation, the standard preventive medication for ischemic stroke patients with AF, in ICH patients with AF are uncertain. PRESTIGE-AF is an international, phase 3b, multi-center, randomized, open, blinded end-point assessment (PROBE) clinical trial that compared the efficacy and safety of direct oral anticoagulants (DOACs) with no DOAC (either no antithrombotic treatment or any antiplatelet drug).
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