Objectives: To estimate the percentage of drivers of motor vehicles under the influence of alcohol circulating during Thursday, Friday, and Saturday night in the metropolitan areas of Guadalajara (municipalities Zapopan and Guadalajara) and León, Mexico, together with their blood alcohol content. To evaluate the impact of the Mexican Initiative for Road Safety (IMESEVI, Phase I) in this respect.
Material And Methods: Drivers who were stopped at sobriety checkpoints during the three above-mentioned nights were given an alcohol test together with a brief questionnaire that asked for sociodemographic and other background variables. The study made use of a pre-post design, with data collections at the start of IMESEVI (June 2008) and a year and a half later (February 2010) in the metropolitan areas of Guadalajara and León. A random sample of 1,299 (pre) and 2,226 (post) drivers participated in the study. The data analysis was based on a hierarchical logistic model for ordinal dependent variables.
Results: At baseline, the breathalyzer showed a positive result in between 17% (Zapopan) and 29% (León) of the drivers, while between 1-3% exceeded the legal maximum of 0.08 g/dl for blood alcohol content in Mexico. The night of observation, the presence of passengers in the vehicle, as well as the driver's civil state and sex affected the probability of a positive result. At the post measurement, the probability of a positive result decreased to about a third of the baseline measurement.
Conclusions: In view of the evidence that links alcohol with the probability of being involved in an accident, drinking and driving prevention programs may contribute significantly to better road safety in Mexico.
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Arch Dermatol Res
January 2025
Instituto de Investigación en Ciencias Biomédicas (IICB), Centro Universitario de Ciencias de La Salud, Universidad de Guadalajara, 44340, Guadalajara, Mexico.
Interleukin-10 (IL-10) is an immunomodulatory molecule that may play an immunosuppressive role in nonmelanoma skin cancer (NMSC), specifically basal cell carcinoma (BCC). We analyzed the role of IL10 promoter variants in genetic determinants of BCC susceptibility and their association with IL10 mRNA and IL-10 serum levels. Three promoter variants (- 1082 A > G, - 819 T > C, and - 592 A > C) were examined in 250 BCC patients and 250 reference group (RG) individuals.
View Article and Find Full Text PDFClin Neuropsychol
January 2025
Center for Neurological Restoration, Neurological Institute, Cleveland Clinic, Cleveland, OH, USA.
Despite significant progress in understanding the factors influencing cognitive function in Parkinson's disease (PD), there is a notable gap in data representation for the Latinx population. This study aims to evaluate the contributors to and disparities in cognitive performance among Latinx patients with PD. A retrospective analysis was conducted based on cross-sectional data encompassing demographic, environmental, motor, and non-motor disease characteristics from the Latin American Research Consortium on the Genetics of PD (LARGE-PD) and the Parkinson's Progression Markers Initiative (PPMI) cohorts.
View Article and Find Full Text PDFSci Rep
January 2025
Laboratorio de Bioinformática Microbiana, Programa Académico de Ingeniería en Biotecnología, Universidad Politécnica de Sinaloa, Carretera Municipal Libre Km. 3 Mazatlán-Higueras, 82199, Mazatlán, Sinaloa, Mexico.
Dispersal is an important life history trait that plays a key role in the demography and evolution of species. We employed a combined approach of DNA sequencing and transmission electron microscopy to examine the changes in the microbiome during the ontogeny and dispersal of the coral-excavating sponge Thoosa mismalolli. The results show that sponge can acquired their associated bacteria via both vertical (VT) and horizontal transmission (HT).
View Article and Find Full Text PDFLancet Rheumatol
January 2025
Infectious Diseases, Asante Three Rivers Medical Center, Grants Pass, OR, USA.
Rev Esp Geriatr Gerontol
January 2025
Servicio de Geriatría, Hospital Universitario Ramón y Cajal (IRYCIS), Ctra. de Colmenar Viejo, km. 9,100, 28034, Madrid C.P. 28034, Mexico.
Background And Aim: To evaluate the association between sarcopenia and metabolic syndrome.
Patients And Methods: A case-control study.
Setting: Geriatric Care Clinic of Metepec (México).
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