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Assessment of Exposure to Polybrominated Dipheny Ethers via Inhalation and Diet in China. | LitMetric
Objective : This paper is to assess the current status of polybrominated diphenyl ethers (PBDEs) contamination in the environment in China and estimate the exposure to PBDEs in non-occupational populations.Methods : A total of 80 research papers published from January 2001 to October 2013 were selected. Geographic information system (GIS) was used in mapping PBDE concentrations and distributions in environmental media. Ni's model was applied to calculate ∑PBDE-intake via the intakes of contaminated food, water and air in the Pearl River Delta and Yangtze River Delta.Results : BDE-209 was found to be the major PBDE congener in the environmental media and food in China. PBDE concentrations varied among different areas, among which the contamination in Guangdong Province was most serious. Daily intake of ∑PBDEs was 225.1-446.0 ng/d for adults in the Pearl River Delta, which was higher than the intake for those living in the Yangtze River Delta (148.9-369.8 ng/d).Conclusion : Atorvastatin can attenuate LPS-induced TNF-α expression and production by activating HO-1 via the ERK and p38 MAPK pathways, suggesting that atorvastatin can be used in treatment of inflammatory diseases such as sepsis, especially in those with atherosclerotic diseases.
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