AI Article Synopsis
- Previous studies hinted at the link between human leukocyte antigen (HLA) and Crohn's disease (CD), but research on HLA class I antigens in Japan was limited.
- In this study with 208 Japanese CD patients and 384 healthy controls, novel positive associations were found between CD and certain HLA class I antigens (HLA-A*02:01 and HLA-A*02:07), along with confirmed associations for HLA-Cw*14:02 and HLA-B*51:01.
- The study also identified negative associations with other HLA antigens (HLA-A*24:02 and HLA-B*07:02) and suggested that HLA class I genes might play dual roles
Article Abstract
Previous studies have suggested that the human leukocyte antigen (HLA) is involved in the etiology of Crohn's disease (CD); however, few reports are available on the association between HLA class I antigens and CD in Japan. In this study, we performed association analysis of HLA class I antigens in CD using 208 Japanese patients and 384 healthy controls. We identified novel positive associations between CD and HLA-A*02:01 (odds ratio (OR)=1.64, P=0.016) and HLA-A*02:07 (OR=2.31, P=0.0067) and confirmed previously reported positive associations between CD and HLA-Cw*14:02 (OR=2.18, P=0.0021) and HLA-B*51:01 (OR=1.70, P=0.033). We also identified novel negative associations between CD and HLA-A*24:02 (OR=0.60, P=0.0047) and HLA-B*07:02 (OR=0.38, P=0.0041). Although the associations were not significant after full Bonferroni correction, we suggested that HLA class I genes have dual functions, susceptibility and resistance in controlling the development of CD.
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| http://dx.doi.org/10.1038/gene.2014.61 | DOI Listing |
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