AI Article Synopsis
- Neuroglobin (Ngb) is a protein discovered in the nervous system in 2000, known for its protective roles against ischemic and hypoxic damage.
- Research shows Ngb's levels increase during ischemic events, but the exact mechanisms of its protection are not completely understood.
- This review emphasizes recent studies on Ngb's protective functions, its involvement in astrocytes and tumors, and its role in promoting neurite outgrowth.
Article Abstract
Neuroglobin (Ngb), a monomeric hexacoordinated heme protein of 17 kDa, was identified in 2000 in the nervous system. Accumulative evidence has proved that Ngb is an endogenous neuroprotective molecule against ischemic/hypoxic insults and oxidative stresses, and in most ischemic conditions, Ngb is up-regulated. The underlying mechanisms, however, are not fully clarified. Here we review the recent experimental findings, mainly focusing on the mechanisms of Ngb's protection and induction during ischemic/hypoxic conditions, the roles of Ngb in astrocytes and tumors, as well as Ngb's function in neurite outgrowth.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1515/bmc-2014-0011 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!