A series of 5,10,15,20-tetraphenylporphinatozirconium(IV) acetylacetonatophenolates containing different phenols as axial ligands [Zr(TPP)(Y)(X)] (TPP = 5,10.15,20-tetraphenyl-21H, 23H-porphine; Y = acac; X = different phenolates) have been synthesized and characterized by various spectrochemical studies. The complexes were also screened for antimicrobial activities. Antifungal activity of some adducts has been carried out against the fungal strain Sclerotium rolfsii. Most of the complexes have shown good antibacterial activity.
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http://dx.doi.org/10.1155/2014/543014 | DOI Listing |
J Am Chem Soc
March 2025
Department of Chemistry, University of California Irvine, Irvine, California 92697, United States.
We previously reported a selenolate-ligated P450 compound I intermediate (SeP450-I) to be more reactive toward C-H bonds than its thiolate-ligated counterpart. To gain insight into how the selenolate axial ligand influences the reactivity of compound I, we have investigated the electronic structure of the SeP450-I intermediate using variable temperature Mössbauer (VTM) spectroscopy. The VTM data indicate that electronic spin relaxation rates are significantly slower in SeP450-I than in P450-I.
View Article and Find Full Text PDFAcc Chem Res
February 2025
Department of Chemistry, Zhejiang University, Hangzhou 310058, China.
ConspectusIn contrast to precious transition metals, such as palladium and rhodium, the development of novel chiral ligands for enantioselective C-H functionalizations catalyzed by earth-abundant, cost-effective, and environmentally friendly 3d metals poses substantial challenges, primarily due to the variable oxidation states, intricate coordination patterns, and limited mechanistic insights. In this Account, we summarize our research endeavors in the development of three novel types of Co(III) catalysis: pseudotetrahedral achiral Cp*Co(III)/chiral carbonyl acid (CCA) catalysis, -generated chiral octahedral cobalt(III) via cobalt/salicyloxazoline (Salox) catalysis, and Co(II)/chiral phosphoric acid (CPA) cooperative catalysis, achieved through strategic chiral ligand design. Our initial objective was to achieve enantioselective C-H functionalization catalyzed by achiral Cp*Co(III) catalysts with external chiral ligands, aiming to circumvent the laborious preparation of chiral CpCo(III) complexes.
View Article and Find Full Text PDFAnn Maxillofac Surg
September 2024
Department of Oral and Maxillofacial Surgery, Faculty of Dental Science, King George Medical University, Lucknow, Uttar Pradesh, India.
Introduction: Platysma myocutaneous flap used for intraoral reconstruction is an axial-pattern flap based on the submental branch of the facial artery; however, its vascular anatomy is complex in nature. Its efficacy in the reconstruction of oral defects following oral cancer resection is well established, even after facial artery ligation. The aim of this study is to evaluate the efficacy of platysma myocutaneous flap in oral submucous fibrosis (OSMF) patients.
View Article and Find Full Text PDFJ Inorg Biochem
May 2025
Department of Chemistry, Saint Louis University, Saint Louis, MO 63103, USA. Electronic address:
Guanine quadruplexes are non-canonical DNA structures with various functions including transcription and translation regulation and telomere protection. These structures are known to bind the heme prosthetic group, resulting in heme-bound G-quadruplexes (heme-G4) that exhibit enhanced peroxidase activity and act as promising biocatalysts. The structure of the heme-G4, specifically how the DNA scaffold interacts with the heme iron, is key in understanding the catalytic mechanism of these DNAzymes.
View Article and Find Full Text PDFCatal Sci Technol
January 2025
Department of Chemistry and Chemical Biology, Stevens Institute of Technology 1 Castle Point Terrace Hoboken NJ 07030 USA
Engineered heme proteins possess excellent biocatalytic carbene N-H insertion abilities for sustainable synthesis, and most of them have His as the Fe axial ligand. However, information on the basic reaction mechanisms is limited, and ground states of heme carbenes involved in the prior computational mechanistic studies are under debate. A comprehensive quantum chemical reaction pathway study was performed for the heme model with a His analogue as the axial ligand and carbene from the widely used precursor ethyl diazoacetate with aniline as the substrate.
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