AI Article Synopsis
- The research focused on creating sugar-based triazolyl azido-alcohols using a one-pot click reaction of glycosyl alkynes and epichlorohydrin in water.
- These newly developed compounds were then used to synthesize bis-triazolyl ethisterone glycoconjugates through a CuAAC reaction.
- The resulting glycoconjugates have potential applications in studying androgen receptor pharmacology and chemical biology.
Article Abstract
Synthesis of sugar based triazolyl azido-alcohols was accomplished via one pot click reaction of glycosyl alkynes with epichlorohydrin in aqueous medium. All the developed triazolyl azido-alcohols were further utilized for the synthesis of bis-triazolyl ethisterone glycoconjugates using CuAAC reaction. The developed triazole-linked ethisterone glycoconjugates would be crucial in androgen receptor pharmacology and chemical biology.
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| http://dx.doi.org/10.1016/j.carres.2014.09.001 | DOI Listing |
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View Article and Find Full Text PDFEfficient synthesis of ethisterone glycoconjugate via bis-triazole linkage.
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Department of Chemistry, Centre of Advanced Study, Faculty of Science, Banaras Hindu University, Varanasi 5, India. Electronic address:
Article Synopsis
- The research focused on creating sugar-based triazolyl azido-alcohols using a one-pot click reaction of glycosyl alkynes and epichlorohydrin in water.
- These newly developed compounds were then used to synthesize bis-triazolyl ethisterone glycoconjugates through a CuAAC reaction.
- The resulting glycoconjugates have potential applications in studying androgen receptor pharmacology and chemical biology.
Click chemistry inspired synthesis of morpholine-fused triazoles.
J Org Chem
June 2014
Department of Chemistry, Centre of Advanced Study, Faculty of Science, Banaras Hindu University, Varanasi-221005, India.
Article Synopsis
- The synthesis of triazolyl azido alcohols involves a one-pot methodology using terminal alkyne and epichlorohydrin, followed by a click reaction with alkyne and azidation of chlorohydroxy triazoles.
- These triazolyl azido alcohols are then used to create various morpholine-fused triazoles that have potential chemotherapeutic benefits.
- The structures of the newly developed compounds were characterized using techniques like IR, NMR, MS, and elemental analysis, with four specifically analyzed through single-crystal X-ray analysis.
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