Background/aims: There are several methods for obtaining tissue samples to diagnose malignant biliary strictures during endoscopic retrograde cholangiopancreatography (ERCP). However, each method has only limited sensitivity. This study aimed to evaluate the diagnostic accuracy of a combined triple-tissue sampling (TTS) method (on-site bile aspiration cytology, brush cytology, and forceps biopsy).
Methods: We retrospectively reviewed 168 patients with suspicious malignant biliary strictures who underwent double-tissue sampling (DTS; n=121) or TTS (n=47) via ERCP at our institution from 2004 to 2011.
Results: Among the 168 patients reviewed, 117 patients (69.6%) were eventually diagnosed with malignancies. The diagnostic sensitivity for cancer was significantly higher in the TTS group than the DTS group (85.0% vs 64.9%, respectively; p=0.022). Furthermore, the combination of brush cytology and forceps biopsy was superior to the other method combinations in the DTS group. With respect to cancer type (cholangiocarcinoma vs noncholangiocarcinoma), interestingly, the diagnostic sensitivity was higher for cholangiocarcinoma in the TTS group than the DTS group (100% vs 69.4%, respectively; p<0.001) but not for the non-cholangiocarcinoma patients (57.1% vs 57.1%, respectively).
Conclusions: TTS can provide an improved diagnostic accuracy in suspicious malignant biliary strictures, particularly for cholangiocarcinoma.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4215455 | PMC |
| http://dx.doi.org/10.5009/gnl13292 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Costs and characteristics of admissions due to ambulatory care-sensitive conditions in children under one year of age in São Paulo, Brazil.
Cien Saude Colet
January 2025
Departamento de Odontologia Social, Faculdade de Odontologia de Piracicaba, Universidade Estadual de Campinas. Campinas SP Brasil.
This research aimed to estimate the direct costs and analyze the epidemiological aspects of ambulatory care-sensitive conditions (ACSC) in children under one year of age, São Paulo municipality, 2011-2022. Total and average costs were calculated according to ACSC diagnosis groups by components (early neonatal, late neonatal, and post-neonatal). The trend in ACSC rates was analyzed using Prais-Winsten generalized linear regression.
View Article and Find Full Text PDF[Performance of the "a body shape index" as a discriminator of obesity and sarcopenic obesity - ELSA-Brasil].
Cien Saude Colet
January 2025
Escola Nacional de Saúde Pública, Fundação Oswaldo Cruz. Rio de Janeiro RJ Brasil.
The scope of this study was to determine the diagnostic performance of ABSI for obesity and sarcopenic obesity, compared to the results of bioimpedance analysis (BIA) and BMI, by sex and age group. It involved a cross-sectional study with 12,793 participants in the second round of ELSA-Brasil (Longitudinal Study of Adult Health in Brazil), which obtained measurements of body fat percentage using BIA and anthropometry, verifying the performance of the diagnostic tests in order to compare the indices. The results showed that for obesity in men in all three age groups, the sensitivity was below 49%.
View Article and Find Full Text PDFProfiles of Early Expressive Phonological Skills-Brazilian Portuguese (PEEPS-BP): a diagnostic accuracy study.
Codas
January 2025
Programa de Pós-graduação em Distúrbios da Comunicação Humana, Departamento de Fonoaudiologia, Universidade Federal de Santa Maria - UFSM - Santa Maria (RS), Brasil.
Purpose: To present the criterion validity, sensitivity, specificity, and cut-off scores for the Profiles of Early Expressive Phonological Skills Test - Brazilian Portuguese (PEEPS-BP) - Expanded List.
Methods: This was a quantitative cross-sectional psychometric study. The sample consisted of 30 children with no identified neurodevelopmental disorders aged 24 to 36 months.
Retinopathy of prematurity: Accuracy of ROPScore and WINROP algorithms in a Brazilian population.
Arq Bras Oftalmol
January 2025
Department of Ophthalmology and Visual Sciences, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, SP, Brazil.
Purpose: To assess the sensitivity and specificity of the retinopathy of prematurity score (ROPScore) and weight, insulin-like growth factor-1, retinopathy of prematurity algorithm in predicting the risk of developing severe retinopathy of prematurity (prethreshold type 1) in a sample of preterm infants in Brazil.
Methods: Retrospective analysis of medical records of preterm infants (n=288) with birth weight of ≤1500 g and/or gestational age of 23-32 weeks in a neonatal unit in Southern Brazil from May 2013 to December 2020 (92 months).
Results: The incidence of confirmed severe retinopathy of prematurity was 6.
Measuring Intentional Communication in Infants at Elevated Likelihood of Autism: Validity, Reliability, and Responsiveness of a Novel Coding Scale.
J Speech Lang Hear Res
January 2025
Program for Early Autism Research, Leadership, and Service, The University of North Carolina at Chapel Hill.
Purpose: Intentional communication acts, or purposefully directed vocalizations and gestures, are particularly difficult for infants at elevated likelihood for eventual diagnosis of autism. The ability to measure and track intentional communication in infancy thus has the potential to aid early identification and intervention efforts. This study assesses the validity of a novel measure of intentional communication intended for use within semistructured caregiver-infant interactions.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!